View Clinical Trial (Medical Research Study)
Chemoprevention of Breast and Prostate Cancers in Shift Workers by Dietary Methylselenocysteine: Effects on Circadian Rhythm and Estrogen Receptor-B Cycling
| City: |
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Piscataway |
| State: |
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New Jersey |
| Zip Code: |
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08854 |
| Conditions: |
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Breast Cancer - Prostate Cancer |
| Purpose: |
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The primary objective of this study is to determine if vitamin supplementation with a
naturally occurring dietary amino acid called organic selenium (i.e., methylselenocysteine)
can restore disruption of circadian rhythm in shift workers.
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| Study Summary: |
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All living cells have a circadian (daily) rhythm which controls a variety of bodily
functions that change throughout the day, including body temperature, sleep, hunger,
activity, hormone levels, etc. The circadian rhythm of the body is controlled by the amount
of light that enters our eyes, so on our planet the length of the rhythm is 24 hours long.
It is therefore reasonable to suspect that upsetting the timing of the rhythm would lead to
changes in body function (as commonly experienced in "jet lag") and that prolonged changes
might even lead to alterations in bodily functions and contribute to disease. This suggests
that people whose service to the community that requires that they often work at night
(nurses, doctors, police, hospital staff, firefighters, airline crews, factory workers,
etc), might be at elevated risk of developing diseases. Studies have shown that women who do
shift work have an elevated risk of breast cancer, probably as a result of altered hormone
levels and cycling. Other studies have shown that vitamin supplementation with a naturally
occurring dietary amino acid called organic selenium (i.e., methylselenocysteine) can
restore this disrupted rhythm and possibly decrease this disease risk. Thus, the purpose of
this study is to investigate whether taking daily selenium (i.e., methylselenocysteine) will
restore the disrupted circadian rhythm in shift workers.
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| Criteria: |
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Inclusion Criteria:
- Permanent night shift schedule
Exclusion Criteria:
- Nutritional supplements that contain selenium
- Pregnant
- Breast feeding
- Heart conditions
- Chronic lung disease
- Cancer therapy (current or past)
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| NCT ID: |
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NCT01611038 |
| Primary Contact: |
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Principal Investigator
Howard M. Kipen, MD, MPH
University of Medicine and Dentistry New Jersey
Kathy Black, PhD
Phone: 848-445-6049
Email: kgblack@eohsi.rutgers.edu
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| Backup Contact: |
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N/A |
| Location Contact: |
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Piscataway, New Jersey 08854
United States
Howard M. Kipen, MD, MPH
Phone: 848-445-6091
Email: kipen@eohsi.rutgers.edu
Site Status: Recruiting |
| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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May 21, 2013 |
| Modifications to this listing: |
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