Assessment of Patients With Multiple Sclerosis (MS) - NCT00001156-20892 (Clinical Trial 111095)
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| City: |
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Bethesda |
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State:
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MD |
| Zip Code: |
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20892 |
| Conditions: |
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Herpesviridae Infection - HTLV-I Infection - Multiple Sclerosis - Tropical Spastic Paraparesis - Vasculitis |
| Purpose: |
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Multiple sclerosis (MS) is a disease of the nervous system. The exact cause of MS is
unknown, but it is believed to be an autoimmune condition. Autoimmune conditions are
diseases that cause the body's immune system and natural defenses to attack healthy cells.
In the case of MS, the immune system begins attacking myelin, the cells that make up the
sheath covering nerves. Without myelin, nerves are unable to transmit signals effectively
and symptoms occur.
This study is directed toward a better understanding of the cause of Multiple Sclerosis
(MS). Researchers will evaluate patients with a tentative diagnosis of MS or other
neurological diseases possibly caused by a immunological reaction. Patients will undergo a
series of three MRIs, taken once a month for three months and submit blood samples for
immunological studies.
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| Study summary: |
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The Neuroimmunology Branch (NIB) conducts research into the cause of immunologically
mediated diseases of the nervous system such as multiple sclerosis (MS). The studies in the
NIB range for studies of the natural history of MS to trials of new experimental therapies.
In order to recruit patients into the various NIB research studies, patients with a
tentative diagnosis are initially seen by the NIB to assess the accuracy of the diagnosis
and to assess the level of disease activity occurring in the patient. Patients seen under
the NIB screening protocol are evaluated in clinic with a complete neurological examination.
Blood studies necessary to eliminate the possibility of many other causes of disease that
may resemble MS are performed. Spinal fluid examination may be preformed if uncertainty
exists with respect to the diagnosis. Finally, patients will have at least one MRI
preformed to assess the consistency with MRI findings expected in MS. Most patients will
have a series of three MRIs done approximately one month apart in order to assess the
frequency of new contrast enhancing lesions occurring in the patient. The level of disease
on MRI is important both from the standpoint of diagnosis as well as determining if the
patient may be eligible for any other NIB protocols. To assess the patient's eligibility
for other NIB studies, the NIB may periodically follow patients in whom the diagnosis is
uncertain or in whom the level of disease activity is not clear for the initial evaluation. |
| Criteria: |
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- INCLUSION CRITERIA:
Diagnosis of possible MS.
Age between 18 and 75.
EXCLUSION CRITERIA:
Clinically significant medical condition other than MS that could cause neurological
dysfunction.
Currently enrolled in an experimental study.
Medical contraindication for MRI.
Psychological contraindications for MRI.
Unable to provide informed consent. |
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If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
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| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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January 31, 2010 |
Modifications to
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Only selected fields are shown, please use the link
above to view all information about this clinical trial. |
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Clinical trials are medical research studies designed to test the safety and/or
effectiveness of new drugs, devices, or treatments in humans. These studies are
conducted worldwide for a range of conditions and illnesses. Learn more about
clinical research and participating in a study at
About Clinical Trials.
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