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View Clinical Trial (Medical Research Study)
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Effects of Arousal and Stress in Anxiety - NCT00026559-20892 (Clinical Trial 113842)
Permalink: http://www.ClinicalConnection.com/exp/ExpandedPatientViewStudy113842.aspx
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| City: |
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Bethesda |
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State:
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MD |
| Zip Code: |
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20892 |
| Conditions: |
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Anxiety Disorder |
| Purpose: |
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This study has several parts. One part will examine the influence of factors such as
personality and past experience on reactions to unpleasant stimuli. Others will examine the
effect of personality and emotional and attentional states on learning and memory.
When confronted with fearful or unpleasant events, people can develop fear of specific cues
that were associated with these events as well as to the environmental context in which the
events occurred via a process called classical conditioning. Classical conditioning has been
used to model anxiety disorders, but the relationship between stress and anxiety and
conditioned responses remains unclear. This study will examine the relationship between cued
conditioning and context conditioning . This study will also explore the acquisition and
retention of different types of motor, emotional, and cognitive associative processes during
various tasks that range from mildly arousing to stressful.
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| Study summary: |
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Classical conditioning theories have long played a role in models and treatment of anxiety
disorders, but important questions remain. One significant issue is the nature of aversive
responses elicited by aversively conditioned stimuli. We argue that the conditioning of
discrete cues models fear, and the conditioning of contextual stimuli and long-duration cues
models anxiety. One aim of this proposal is to characterize the psychophysiological,
emotional, and biological concomitants of these different types of conditioning. Another
aim is to examine the impact of prior stress on conditioned fear responses. Stress affects
limbic regions that are implicated in learning and memory, as well as mood and anxiety
disorders, suggesting that stress impairs limbic-mediated components of associative
learning. We hypothesize that stress will have little impact on implicit motor learning, but
will affect associative learning that is dependent on the hippocampus. We will explore the
effect of stress on acquisition and retention of different types of motor
(cerebellum-dependent), emotional (amygdala-dependent), and cognitive
(hippocampus-dependent) associative processes. |
| Criteria: |
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- INCLUSION CRITERIA:
Subjects will be healthy volunteers ages 18-50 recruited through advertisements in the
local media.
Subjects will be free of current or past psychopathology and organic central nervous
system disorders.
EXCLUSION CRITERIA:
Any current ongoing medical illness; psychiatric (Axis I disorders) or neurological
disorder (including seizure), current substance abuse, or current psychotropic medication
are grounds for exclusion.
In addition, subjects will be excluded from CO(2) studies if they suffer from current or a
history of cerebral aneurysm, hypertension, angina, asthma, or cardiovascular problems.
Pregnancy will also be an exclusion factor.
Female participants in the stress/learning study will be excluded if they suffer from
premenstrual syndrome or irregular menses.
Subjects participating in a shock experiment will be excluded if they have neurological
symptoms of the wrist and arms (e.g., carpal tunnel syndrome). |
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| Study is available at: |
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National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, MD 20892
United States
Primary Contact:
Patient Recruitment and Public Liaison Office
Email: prpl@mail.cc.nih.gov
Phone: (800) 411-1222 |
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If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
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| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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March 15, 2010 |
Modifications to
this listing: |
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Only selected fields are shown, please use the link
above to view all information about this clinical trial. |
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Clinical trials are medical research studies designed to test the safety and/or
effectiveness of new drugs, devices, or treatments in humans. These studies are
conducted worldwide for a range of conditions and illnesses. Learn more about
clinical research and participating in a study at
About Clinical Trials.
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