| City: |
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Orange |
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State:
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CA |
| Zip Code: |
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92668 |
| Conditions: |
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Attention Deficit Disorder With Hyperactivity |
| Purpose: |
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Attention Deficit Hyperactivity Disorder (ADHD) is the most common behavioral disorder in
childhood, affecting 3-5% of children between the ages of 7 and 17. Family studies suggest
that there is a genetic component to ADHD. Scientists believe that it is a complex disorder
in which two or more genes may be involved.
Potentially eligible families will be asked to give written consent to participate and will
be asked to complete questionnaires for each member in the family. In addition, an interview
will be administered to the parent of minors enrolled in the study to determine their
eligibility for being in the study. This screening tool is computerized and will take
approximately 45 minutes to administer per child.
Once screenings are completed, a blood collection kit will be sent to the family to take to
their local medical care provider, have blood samples drawn and sent to NIH. There is no
cost to the family to participate. We would like to enroll entire families, with both
parents and all children.
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| Study summary: |
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Attention Deficit Hyperactivity Disorder (ADHD) is a prevalent neuropsychiatric disorder
affecting 5% of children worldwide. A study of the hypothesis that Attention Deficit
Hyperactivity Disorder (ADHD) is a genetically influenced brain disorder has been undertaken
using a two armed approach: 1) Isolated population analysis from a large, extended pedigree
study done in Colombia, South America in a population isolate called the Paisa have been
studied for the last 7 years; and a recently added second isolated in USA from Amish
population at Lancaster, Co Pennsylvania; with different background and environmental
influences, and 2) a U.S. based study of nuclear families with at least one affected child
and at least one sibling (either affected or unaffected), and their parents. Following
careful phenotyping, DNA from blood samples from these two genetically different groups will
be analyzed through a genomewide scan for linkage and positional candidate approach to
search for genes associated with ADHD. In addition comparison of genetic-environment
interactions will be done on these two different populations. Genetic influence are to
modulate biological aspects in cognition and behavioral manifestations. The prefrontal
cortex and its connections is known to play a very important role in the processing of
emotions and impulsivity. It is considered the primary biological component of a brain
circuit that would explain the main clinical characteristics present in ADHD phenotype.
Measurement of brain metabolites in this region may be very useful in phenotyping ADHD.
Thus, after identification of specific genotype implicated in ADHD risk in the Colombian
population, in a subset of already recruited individuals, phenotyping will include proton
magnetic resonance spectroscopy (H MRS) to detect biochemical phenotypes which may be
correlated with genetic markers for ADHD. Additional analysis for potential
genetic-environment interactions will be done to compare isolated populations in different
environments. Identification of a biological marker to be used to support and confirm
clinical diagnosis is highly desirable. |
| Criteria: |
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- INCLUSION CRITERIA:
For both the U.S. and the Columbian Studies, we plan to obtain blood samples from subjects
meeting the following criteria:
Children, ages 7-17, affected with ADHD with siblings who are either affected or
unaffected, and their parents. (in the Columbian Study, we will also gather information
and blood samples from extended families).
Adult participants 18 years or older selected for MRS from the Paisa population will be
included if they:
1. share the haplotype that is in linkage disequilibrium at chromosome 11 p
2. do not have devices such as pace makers, cochlear implants, metal clips in the brain,
etc that would preclude them from undergoing magnetic resonance technology
3. are not pregnant (pregnancy test will be administered) or breastfeeding
4. do not have a mental condition such as claustrophobia which would make magnetic
resonance technology unacceptable to them.
In both arms of the study, both male and female probands will be accepted of any
ethnic background as long as they meet the criteria listed above. While there is a
preponderance of males with ADHD, all clinics see both male and female research
participants. Also, in most cases the family unit will involve the mother as well as
the father for testing. Hispanic families will be specially enrolled in the Colombian
arm.
For the H MRS study, no one is excluded based on race, gender, or socioeconomic
status.
However, participants must meet the inclusion criteria described.
EXCLUSION CRITERIA:
Exclude the following (if the condition could cause false positive ADHD):
- Prematurity
- Neurological conditions
- Cardiac surgery
- Prenatal drug exposure
- Hydrocephaly
- Mental Retardation (IQ< 80)
- Known genetic syndromes
- Known CNS disorders
- Known lead toxicity
- Tourette Disorder
- Obsessive-Compulsive Disorder
- Major Depression on both proband and affected sibling
- Pervasive Developmental Disorder
- Age under 7 years old
- Autism
- Other Psychoses
- Post Traumatic Stress Disorder
- Language Disorder (if known)
- Severe Sensory Impairment (visual and hearing)
No bilineal families for statistical reasons are to be included, i.e. families in
which both father and mother are known to be affected with ADHD. In order to involve
either parent, there must be affected siblings.
Include, but note:
- Oppositional Defiant Disorder
- Conduct Disorder
- Tic Disorder
- Obsessive/Compulsive Symptoms
- Anxiety/Phobias
- Learning Disabilities |
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| Study is available at: |
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University of California, Irvine Medical Center
Orange, CA 92668
United States
Primary Contact:
Patient Recruitment and Public Liaison Office
Email: prpl@mail.cc.nih.gov
Phone: (800) 411-1222 |
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If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
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| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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March 21, 2011 |
Modifications to
this listing: |
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Only selected fields are shown, please use the link
above to view all information about this clinical trial. |
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