Effect of Dietary Amino Acid Profile on Lipoprotein Metabolism, Vascular Reactivity and Inflammatory Markers - NCT00175084-02111 (Clinical Trial 128994)
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Boston |
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State:
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MA |
| Zip Code: |
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02111 |
| Conditions: |
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Hyperlipidemias - Metabolic Syndrome X - Cardiovascular Diseases |
| Purpose: |
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The aim of this study is to explore the significance of the Lys:Arg ratio on responses of
lipids and lipoprotein concentrations to dietary proteins and to evaluate the effects of
dietary Lys:Arg on cardiovascular disease risk factors and endothelial function.
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| Study summary: |
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Findings from early studies in a variety of experimental models of atherosclerosis on the
effect of dietary protein suggested that proteins from vegetable sources are less
cholesterolemic and atherogenic than proteins from animal sources. Throughout the later part
of the 20th century there has been sporadic interest in the effect of protein type and amino
acid profiles on blood lipid concentrations and atherosclerosis. A major focus for this
evaluation has been to compare proteins based on their amino acid profile, often expressed
as lysine (Lys) to arginine (Arg) ratio (Lys:Arg). While animal studies have provided
important information regarding the significance of the Lys:Arg in determining the
cholesterolemic response to a dietary protein, interpretation of these data must be done
with caution since most of the studies have been conducted in animal models that have a
different lipoprotein distribution and metabolism than humans. Moreover, the mechanistic
insights of this response are yet to be determined. While the favorable effects of Arg on
endothelial function appear to be consistent when Arg is administered using a supplement,
the effects of dietary Arg naturally present in protein rich foods has yet to be determined.
The aim of this proposal is to explore the significance of the Lys:Arg ratio on responses of
lipids and lipoprotein concentrations to dietary proteins and to evaluate the effects of
dietary Lys:Arg on cardiovascular disease risk factors and endothelial function. |
| Criteria: |
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Inclusion Criteria:
- Age: 50-85 years
- LDL-C concentrations >120 mg/dL
Exclusion Criteria:
- Use of medications known to affect lipid metabolism
- Established CVD
- Renal disease
- Liver disease
- Thyroid disease unless controlled with medication for at least 6 months
- Type I and II diabetes
- Irritable bowel syndrome
- Chronic use of prescription anti-inflammatory medications
- Smoking
- Alcohol intake >7 alcoholic drinks per week
- Unwillingness to maintain body weight during participation in the study
- TG > 400 mg/dL
- Unwillingness to adhere to diet and study protocol
- Weight gain or loss of more than 15 lb within 6 months prior to enrollment |
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If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
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| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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January 18, 2010 |
Modifications to
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Only selected fields are shown, please use the link
above to view all information about this clinical trial. |
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Clinical trials are medical research studies designed to test the safety and/or
effectiveness of new drugs, devices, or treatments in humans. These studies are
conducted worldwide for a range of conditions and illnesses. Learn more about
clinical research and participating in a study at
About Clinical Trials.
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