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Dehydroepiandrosterone (DHEA) in Systemic Lupus Erythematosus (SLE) for Coronary Artery Disease (CAD) Prevention - NCT00189124-48109(Clinical Trial 129534)



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City:  Ann Arbor
State:  
MI
Zip Code: 48109
Conditions: Systemic Lupus Erythematosus
Purpose: The purpose of this study is to evaluate the effect of DHEA on endothelial dysfunction in patients with systemic lupus by measuring: 1. changes in brachial artery flow-mediated dilatation (FMD) and 2. changes in biomarkers of cardiovascular risk. Patients will be enrolled in a randomized, double-blinded crossover trial of DHEA or placebo for ten weeks, then crossed over to the alternate treatment arm after a six-week washout period. HYPOTHESIS: Dehydroepiandrosterone (DHEA) administration in premenopausal women with SLE modifies cardiovascular risk by improving vascular endothelial function and other biomarkers associated with cardiovascular heart disease.
Study summary:
Criteria: Inclusion Criteria: - Female - Member of the Michigan Lupus Cohort - Meet the American College of Rheumatology (ACR) criteria for SLE - Premenopausal Exclusion Criteria: - Smoker - Diabetic - Prednisone dose > 10 mg
Study is available at: University of Michigan
Ann Arbor, MI 48109
United States

Primary Contact:
Wendy Marder, MD
Email: wmarder@umich.edu
Phone: 734-936-1166

Secondary Contact:
Wendy Marder, MD
Email: wmarder@umich.edu
Phone: (734) 936-1166
If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
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Data Source: ClinicalTrials.gov
Date Processed: March 21, 2011
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