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An Open Label Trial for Treating Carpometacarpal Osteoarthritis of the Thumb: Pilot Study - NCT00198029-10021(Clinical Trial 129924)



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City:  New York
State:  
NY
Zip Code: 10021
Conditions: Carpometacarpal Osteoarthritis
Purpose: The purpose of this study is to find out if hyaluronan, an injectable medication for knee arthritis, also works for arthritis at the base of the thumb. This study will also evaluate how good ultrasound is at visualizing medication in the thumb joint. We are no longer recruiting for this part of the open label trial. In a sub-study including 20 age-matched subjects without arthritis to validate the manual Strength-Dexterity Test. We are currently recruiting subjects without arthritis for our control sub-study.
Study summary:
Criteria: Inclusion Criteria: - Radiographic evidence of at least moderate narrowing (joint space < 1mm) or the presence of osteophytes or sclerosis at the CMC joint - Patient complaint of unacceptable pain despite modification of activity, a trial of splinting and a therapeutic dose of NSAIDS - If bilateral disease, only the most severely involved hand, (as defined by VAS for pain), will be entered in the study. - Proficiency in English. Exclusion Criteria: - Previous bad injury to the thumb - Previous hand surgery on the study thumb - Known hand comorbidities (i.e. carpal tunnel syndrome, de Quervains Tenosynovitis etc) - Rheumatoid arthritis or lupus - Bleeding problems - Being on blood thinners (except aspirin) - Known allergies to any of the medications being used - Allergies to chicken products - Current use of oral steroids - Cancer that is not cured or in remission - Severe diabetes - A serious infection somewhere else in the subject's body
Study is available at: Hospital for Special Surgery
New York, NY 10021
United States

Primary Contact:
Lisa Mandl, MD MPH
Phone: 212-774-2555

Secondary Contact:
Nadia Baranchuk
Email: baranchukn@hss.edu
Phone: 212-774-2960
If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
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Data Source: ClinicalTrials.gov
Date Processed: March 21, 2011
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