Cardiac Rhythm Abnormalities in Patients With Refractory Epilepsy at High Risk for Sudden Death - NCT00203333-19107 (Clinical Trial 130157)
Permalink: http://www.ClinicalConnection.com/exp/ExpandedPatientViewStudy130157.aspx
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| City: |
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Philadelphia |
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State:
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PA |
| Zip Code: |
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19107 |
| Conditions: |
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Refractory Epilepsy - Arrhythmia - Sudden Death |
| Purpose: |
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People with epilepsy are at a higher risk for sudden unexpected death than the general
population. Sudden unexpected death in epilepsy (SUDEP) is a major cause of death in this
population, accounting for 10-50% of deaths for those with epilepsy. The risk for SUDEP is
particularly high for those with refractory epilepsy. Several lines of evidence support a
cardiac mechanism for SUDEP.
This study plans to determine:
1. the frequency and types of cardiac arrhythmias that occur in this population and
2. whether these are increased above the general population in the same age group.
Additionally, these data will be correlated to specific clinical data, including seizure
history, anticonvulsant medications, and any accompanying clinical symptoms.
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| Study summary: |
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By employing long-term electrocardiographic monitoring, this study plans to determine:
1. the frequency and types of cardiac arrhythmias that occur in patients with uncontrolled
seizures and
2. whether these are increased above the general population in the same age group.
The specific aims:
1. Identify the types, frequency, and duration of cardiac arrhythmias that occur in
patients with refractory epilepsy and compare these data to available normative data.
2. Correlate abnormal heart rates and rhythms to specific clinical data:
1. seizure type,
2. seizure frequency,
3. probable location of seizure onset in the brain, when such data are available,
4. duration of seizures, and
5. type(s) and number of anticonvulsant medications being used.
3. Correlate cardiac arrhythmias to clinical symptoms |
| Criteria: |
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Inclusion Criteria:
- Refractory epilepsy
Exclusion Criteria:
- Other pre-existing heart conditions |
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| Study is available at: |
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Thomas Jefferson University
Philadelphia, PA 19107
United States
Primary Contact:
Megan Morales, BA
Email: megan.morales@jefferson.edu
Phone: 215-955-4672
Secondary Contact:
Gwen Taylor, BA
Email: gwen.taylor@jefferson.edu
Phone: 215-955-4673 |
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If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
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| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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March 15, 2010 |
Modifications to
this listing: |
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Only selected fields are shown, please use the link
above to view all information about this clinical trial. |
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Clinical trials are medical research studies designed to test the safety and/or
effectiveness of new drugs, devices, or treatments in humans. These studies are
conducted worldwide for a range of conditions and illnesses. Learn more about
clinical research and participating in a study at
About Clinical Trials.
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