Influenza Vaccine in Lung Transplant Patients - NCT00205270-53792 (Clinical Trial 130189)
Permalink: http://www.ClinicalConnection.com/exp/ExpandedPatientViewStudy130189.aspx
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Madison |
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State:
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WI |
| Zip Code: |
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53792 |
| Conditions: |
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Influenza |
| Purpose: |
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Research Question: How do antibody and T cell responses following influenza vaccine compare
among lung transplant patients, patients waiting for lung transplantation and healthy
individuals?
Experimental Design: This interventional parallel group study will compare influenza
vaccine induced immune responses in three groups: lung transplant patients, individuals
waiting for lung transplantation and healthy individuals.
Current and Future Research Activities: Blood will be drawn for these measures of vaccine
induced antibody response before and 2 to 4 weeks after immunization. Another blood draw
will be obtained from up to 30 individuals from among the three groups for measures of T
cell response to immunization. The third blood draw will be done during months 1 to 5
following influenza immunization. Genetic material (DNA) will be obtained from cells in
the blood to look for genetic markers that may be associated with influenza vaccine
response. Blood draws and immunization for the healthy participants will be done at the
General Clinical Research Center (GCRC) or in the Clinical Research Facility in Rennebohm
Hall. The blood draws for the pre-transplant and post-transplant patients will be
coordinated with clinically indicated laboratory tests in order to avoid additional
venipunctures. Influenza immunization is part of the routine clinical care of patients with
lung disease, and only the immune response data will be considered part of the research
study.
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| Study summary: |
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| Criteria: |
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Inclusion Criteria:
- Receiving care pre- or post-lung transplant at University of Wisconsin Hospital
- Healthy adult
Exclusion Criteria:
- Allergy to eggs
- Moderate to severe febrile illness
- Active treatment for acute rejection
- Received season's influenza vaccine prior to enrollment |
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| Study is available at: |
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University of Wisconsin
Madison, WI 53792
United States
Primary Contact:
Mary S Hayney, PharmD
Email: mshayney@pharmacy.wisc.edu
Secondary Contact:
Mary S Hayney, PharmD
Email: mshayney@pharmacy.wisc.edu |
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If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
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| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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March 15, 2010 |
Modifications to
this listing: |
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Only selected fields are shown, please use the link
above to view all information about this clinical trial. |
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Clinical trials are medical research studies designed to test the safety and/or
effectiveness of new drugs, devices, or treatments in humans. These studies are
conducted worldwide for a range of conditions and illnesses. Learn more about
clinical research and participating in a study at
About Clinical Trials.
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