Effect of Menstrual Cycle on CNS Processing of Gut Stimuli in IBS and Control - NCT00219531-17033 (Clinical Trial 130821)
Permalink: http://www.ClinicalConnection.com/exp/ExpandedPatientViewStudy130821.aspx
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| City: |
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Hershey |
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State:
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PA |
| Zip Code: |
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17033 |
| Conditions: |
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Irritable Bowel Syndrome |
| Purpose: |
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The hypothesis of the study is that women perceive intestinal stimulation (rectal balloon
distention) differently in different phases of the menstrual cycle, i.e there is an effect
of hormones on the sensory pathway, and that this difference is reflected in the Central
Nervous System processing of this signal. We also hypothesize that there is a difference in
perception between control subjects and subjects with the irritable bowel syndrome.
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| Study summary: |
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There is discrepancy in the literature concerning the effect of the menstrual cycle on bowel
function and pain syndromes such at irritable bowel syndrome. In addition, recent studies
indicate a difference in the CNS processing of rectal stimulation in normal subjects and
patients with IBS. This study will determine the differences in the perception of rectal
balloon distention in the follicular and luteal phases of the menstrual cycle, in control
subjects with no bowel symptoms and volunteers with IBS, and will compare the CNS processing
of this signal using functional MRI , again in the two phases of the menstrual cycle.
Comparisons: between control subjects without GI symptoms and those with irritable bowel
syndrome. |
| Criteria: |
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Inclusion Criteria:
- controls - normal bowel function
- Irritable bowel syndrome - Rome II criteria
- Normal menstrual cycle
Exclusion Criteria:
- irregular menses
- pregnancy
- use of psychotropic medication
- claustrophobia
- metal implants
- metal in eyes |
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| Study is available at: |
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Hershey Medical Center
Hershey, PA 17033
United States
Primary Contact:
kathyrn Kaylor
Email: kkaylor@psu.edu
Phone: 717-531-8495
Secondary Contact:
Ann Ouyang, MD
Email: aouyang@psu.edu
Phone: 717-531-8741 |
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If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
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| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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March 15, 2010 |
Modifications to
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Only selected fields are shown, please use the link
above to view all information about this clinical trial. |
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Clinical trials are medical research studies designed to test the safety and/or
effectiveness of new drugs, devices, or treatments in humans. These studies are
conducted worldwide for a range of conditions and illnesses. Learn more about
clinical research and participating in a study at
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