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View Clinical Trial (Medical Research Study)
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Exercise and Physical Fitness for Persons With Knee Osteoarthritis - NCT00265447-65211 (Clinical Trial 133976)
Permalink: http://www.ClinicalConnection.com/exp/ExpandedPatientViewStudy133976.aspx
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| City: |
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Columbia |
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State:
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MO |
| Zip Code: |
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65211 |
| Conditions: |
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Knee Osteoarthritis |
| Purpose: |
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The purpose of this project is to establish evidence to support specific, targeted exercise
and rehabilitation recommendations for people over 50 with osteoarthritis of the knee.
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| Study summary: |
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Physical disability and poor health often accompany knee osteoarthritis (OA), particularly
as people age. This decline in function and quality of life is a complex phenomenon
associated with numerous factors including pain, poor physical fitness, obesity,
co-morbidity, low self-efficacy and lower extremity impairments. Furthermore, the effects of
age, which have not been well studied in OA, must be considered. In addition to the
functional losses associated with knee OA and aging, low levels of daily physical activity
and exercise are common problems in this population for whom arthritis is a major reason for
activity limitation. Evidence is accumulating that exercise can enhance health and quality
of life and modify a number of the factors associated with disability. There is, however,
little specific information to guide exercise prescription in the diverse population of
people with knee OA. Although general benefit of exercise has been demonstrated, it is time
to focus research questions on the specific types of exercise that produce specific effects;
and for whom particular exercises are the most useful. Additionally, exercise has shown
short term benefit, but how best to maintain gains and sustain exercise behaviors in
self-directed and community settings is virtually untested. These questions are relevant to
all people with knee OA, and become even more important as people grow older, become more
sedentary and are at greater risk for frailty, poor health and disability.
This study is designed to: determine the efficacy of specific types of exercise by examining
the effects of training on physiologic adaptations and physical performance; determine the
effectiveness of a comprehensive exercise protocol performed in a supervised but non-medical
setting, and describe the interaction of personal characteristics and disease severity with
individual response to a particular exercise regimen. |
| Criteria: |
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Inclusion Criteria:
community-dwelling, physician diagnosed osteoarthritis of the knee, willingness to
exercise regularly, willingness to perform 3 testing sessions over a 6-month period,
ability to exercise safely at a moderate level of intensity, knee osteoarthritis by
clinical criteria,
WOMAC Scores as follows:
PAIN:"mild" pain on 2 items or "moderate" pain on 1 item; PHYSICAL FUNCTION: "mild"
difficulty in 4 items or "moderate" difficulty in 2 items -
Exclusion Criteria:
age<50,inability to exercise and ambulate independently, physical limitation secondary to
a condition that is not modifiable by exercise (e.g., active cancer), knee replacement
(past or scheduled), total hip joint replacement less than 6 months ago, current
participation in regular conditioning exercise, participation in another research study,
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| Study is available at: |
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University of Missouri
Columbia, MO 65211
United States
Primary Contact:
Peggy S Nigh, BGS
Email: pt_research@missouri.edu
Phone: 573-882-4012 |
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If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
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| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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March 15, 2010 |
Modifications to
this listing: |
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Only selected fields are shown, please use the link
above to view all information about this clinical trial. |
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Clinical trials are medical research studies designed to test the safety and/or
effectiveness of new drugs, devices, or treatments in humans. These studies are
conducted worldwide for a range of conditions and illnesses. Learn more about
clinical research and participating in a study at
About Clinical Trials.
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