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Familial Barrett's Esophagus - NCT00288119-68131(Clinical Trial 137423)



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City:  Omaha
State:  
NE
Zip Code: 68131
Conditions: Barrett's Esophagus - Esophageal Neoplasm
Purpose: This is a multi-center study whose aim is to define the epidemiology and genetics of Barrett's esophagus and adenocarcinoma. The researchers have studied families affected with Barrett's esophagus and esophageal adenocarcinoma, a specific type of cancer of the esophagus. They have found that Barrett's and esophageal cancer occur at a younger age in these families suggesting that familial Barrett's esophagus is a genetically inherited disease.
Study summary: This research study is trying to determine whether Barrett's esophagus and associated esophageal cancers, specifically esophageal adenocarcinoma are inherited in certain families. Persons who are affected with Barrett's esophagus or esophageal cancer (adenocarcinoma type) are asked to complete a questionnaire that determines their habits and asks a detailed family history. Family members of patients seen at University Hospitals of Cleveland and the Cleveland Clinic are also being recruited for screening tests of their esophagus. The investigators plan to eventually screen family members at all participating institutions. This research will eventually lead to the identification of inherited genetic changes that cause Barrett's esophagus and esophageal cancer. It will help the investigators develop better methods for preventing or identifying esophageal cancer at an early curable stage.
Criteria: Eligible cases will be defined as those patients and their family members who meet the following criteria: - Barrett's esophagus confirmed by review of pathology and endoscopy report or adenocarcinoma of the esophagus or family members of person with Barrett's esophagus or adenocarcinoma of the esophagus. - Male or female age 18 or older at time of enrollment or male or female less than 18 years of age at time of enrollment with parental consent. - Ability to give informed consent, if patient is age 18 or older.
Study is available at: Creighton University Medical Center
Omaha, NE 68131
United States

Primary Contact:
Sumeet Mittal, MD
Email: SumeetMittal@creighton.edu
Phone: 402-280-4161

Secondary Contact:
Amitabh Chak, MD
Email: axc22@po.cwru.edu
Phone: 216-844-5385
If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
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Data Source: ClinicalTrials.gov
Date Processed: March 21, 2011
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