View Clinical Trial (Medical Research Study)
Isolation and Characterization of Mammary Stem Cells - NCT00340392-20892(Clinical Trial 145959)
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| City: |
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Bethesda |
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State:
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MD |
| Zip Code: |
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20892 |
| Conditions: |
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Stem Cells |
| Purpose: |
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Background:
- Cancer stem cells in breast cancer have been identified as a small population of tumor
cells whose self-renewal mechanism is highly deregulated. This deregulation seems to be
necessary for cancer to develop.
- These cells can be identified by certain surface markers that overlap with markers
associated with normal embryonic stem cells.
Objective: To isolate tumor stem cells using the same methods generally used to isolate
human embryonic stem cells.
Eligibility:
- Tissue samples will be obtained from the human cooperative network.
- Samples will include normal tissues from individuals who have no opportunistic diseases
and from individuals with cancer.
Design: Breast cancer stem cells will be isolated, grown in the laboratory and
characterized.
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| Study summary: |
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Cancers are composed of heterogeneous populations of cells with varying degrees of
proliferative capacity and ability to reconstitute tumors when transplanted into nude or
SCID mice.
Recently, cancer stem cells have been identified as a small population of tumor cells which
possess the stem cell properties in that their self-renewal pathway is highly deregulated.
This deregulation seems to be the prerequisite for the development of cancer. |
| Criteria: |
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- INCLUSION CRITERIA:
The tissue samples will come from the human cooperative network. They have their own set
of criteria. We are requesting tissue samples from individuals that are normal as well as
those who have cancer.
EXCLUSION CRITERIA:
The tissue samples will come from the human cooperative tissue network and we are asking
for normal samples from individuals who don't have any opportunistic diseases. |
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| Study is available at: |
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National Cancer Institute (NCI), 9000 Rockville Pike
Bethesda, MD 20892
United States
Primary Contact:
Jean-Pierre Gillet, Ph.D.
Email: gilletjp@mail.nih.gov
Phone: (301) 435-6307 |
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If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
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| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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March 21, 2011 |
Modifications to
this listing: |
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