View Clinical Trial (Medical Research Study)
The Effects of Potassium Citrate on Bone Metabolism - NCT00357331-10021(Clinical Trial 147079)
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New York |
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State:
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NY |
| Zip Code: |
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10021 |
| Conditions: |
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Bone Diseases, Metabolic - Osteoporosis, Postmenopausal |
| Purpose: |
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Skeletal buffering of chronic acid loads may contribute to a significant amount of bone loss
over time. Evidence from a few small short-term studies suggests that basic compounds,
namely potassium citrate and potassium bicarbonate may reduce bone loss and improve bone
density.
The purpose of this study is to evaluate the effects of potassium citrate on bone
metabolism. We hypothesize that administration of potassium citrate to postmenopausal women
with osteopenia will reduce bone resorption and improve bone mineral density.
Postmenopausal women with osteopenia (T score between -1.0 and -2.5) and no history of
fracture will be randomized to either daily potassium citrate or placebo for one year.
Primary outcomes will be markers of bone turnover, which will be measured over 12 months.
Secondary outcomes will be bone mineral density, compliance, and adverse events.
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| Study summary: |
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| Criteria: |
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Inclusion Criteria:
- Postmenopausal women, more than 2 years post menopause
- Osteopenia, defined as a T score at the lumbar spine or total hip between -1.0 and
-2.5
- No history of prior fragility fracture
Exclusion criteria:
- Renal insufficiency
- Use of potassium sparing diuretics
- Use of potassium supplements
- Hyperkalemia
- Secondary causes of osteoporosis or metabolic bone disease
- Delayed gastric emptying
- esophageal compression, intestinal obstruction or stricture
- use of anticholinergic medication
- active urinary tract infection. |
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| Study is available at: |
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Weill Cornell Medical College
New York, NY 10021
United States
Primary Contact:
Kara Rysman, M.D.
Email: rysmank@mskcc.org
Secondary Contact:
Kara Rysman, M.D.
Email: rysmank@mskcc.org |
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If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
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| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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March 21, 2011 |
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