A Comparison of Adherence Rates to Ritonavir and Its Accompanying Protease Inhibitor - NCT00432783-10467 (Clinical Trial 162135)
Permalink: http://www.ClinicalConnection.com/exp/ExpandedPatientViewStudy162135.aspx
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| City: |
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Bronx |
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State:
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NY |
| Zip Code: |
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10467 |
| Conditions: |
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HIV Infections |
| Purpose: |
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Pharmacologic boosting of protease inhbitors with ritonavir has become standard practice in
antiretroviral therapy. Patients are instructed to take ritonavir at the same time as its
accompanying protease inhibitor. However, ritonavir is unpopular with many patients because
of its large size and because of the recommended need for refrigeration. This study will
test the hypothesis that adherence to ritonavir is inferior to adherence to its accompanying
protease inhibitor in patients receiving such therapy.
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| Study summary: |
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The study staff will employ MEMS caps to prospectively measure adherence to ritonavir and
its accompanying protease inhibitor over 24 weeks of follow-up. Paired sample t-tests will
be employed to compare adherence to the two agents, and secondary analyses will be conducted
to evaluate the chronologic concordance of ritonavir and accompanying protease inhibitor
dosing. |
| Criteria: |
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Inclusion Criteria:
- HIV infection, age>18 years, receiving therapy with ritonavir-boosted atazanavir or
fosamprenavir, willingness to use MEMS caps, willingness to provide informed consent
Exclusion Criteria:
- Treatment with any medication that is contraindicated in combination with ritonavir
or its accompanying protease inhibitore |
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If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
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| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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November 3, 2009 |
Modifications to
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Only selected fields are shown, please use the link
above to view all information about this clinical trial. |
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Clinical trials are medical research studies designed to test the safety and/or
effectiveness of new drugs, devices, or treatments in humans. These studies are
conducted worldwide for a range of conditions and illnesses. Learn more about
clinical research and participating in a study at
About Clinical Trials.
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