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Changes in Eye Pressure and Anterior Chamber Depth With Oral Endothelin Antagonist Therapy - NCT00452283-80045(Clinical Trial 166635)



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City:  Aurora
State:  
CO
Zip Code: 80045
Conditions: Glaucoma - Pulmonary Hypertension
Purpose: There is growing evidence that a cause of glaucoma is linked to circulatory problems and poor auto-regulation of blood flow to the optic nerve. Pulmonary hypertension (PH)is a disease characterized by low oxygen levels in the blood and altered blood circulation. The decrease in oxygen delivery to the optic nerve could lead to the loss of nerve fiber layer(NFL)in the retina and the resulting visual field compromise. This situation is characteristic of glaucoma. The ability to identify NFL thinning early could lead to earlier diagnosis of glaucoma and more effective treatment to limit dysfunction from visual field loss. We hypothesize that the rate of structural damage to the NFL, a feature of glaucoma, is higher in patients with PH than expected in healthy populations lacking this disease.
Study summary:
Criteria: Inclusion Criteria: - diagnosed with pulmonary hypertension - between the ages of 18 and 80 years - ability to undergo the various ocular exams. Exclusion Criteria: - patients with other diseases that could affect the nerve fiber layer - specials populations; ie children, pregnancy, lactating females, prisoners
Study is available at: Rocky Mountain Lions Eye Institute
Aurora, CO 80045
United States

Primary Contact:
Tim Byrne
Email: tim.byrne@uchsc.edu
Phone: 720-848-5051

Secondary Contact:
Tim Byrne
Email: tim.byrne@uchsc.edu
Phone: 720-848-5051
If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
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Data Source: ClinicalTrials.gov
Date Processed: March 22, 2011
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