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Cytokine Profiles in Children With Obstructive Sleep Apnea - NCT00456573-60637(Clinical Trial 167445)



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City:  Chicago
State:  
IL
Zip Code: 60637
Conditions: Obstructive Sleep Apnea Syndrome
Purpose: The purpose of this study is to compare the cytokine profile of tonsillar and peripheral blood mononuclear cells in patients with obstructive sleep apnea (OSA) and to compare the blood mononuclear cell cytokine secretion profile between patients with obstructive sleep apnea and controls without apnea.
Study summary: We will recruit subjects with OSA about to undergo adenotonsillectomy and collect a blood sample and portion of their tonsils after the induction of general anesthesia. The mononuclear cells will be isolated from both these tissues and stimulated with different markers and cytokines assayed and compared. We will also recruit patients with no symptoms of OSA undergoing unrelated elective surgery and ascertain the absence of OSA by having the parents fill out a sleep questionnaire. We will then collect blood samples from these patients after the induction of anesthesia and examine the cytokine secretion profile and compare it to that of the children with OSA.
Criteria: Inclusion Criteria: - OSA documented by polysomnography and clinical symptoms. - Patients with no symptoms of OSA and negative sleep questionnaire. Exclusion Criteria: - Significant systemic disease except mild asthma
Study is available at: University of Chicago
Chicago, IL 60637
United States

Primary Contact:
Fuad M Baroody, MD
Email: fbaroody@surgery.bsd.uchicago.edu
Phone: 773-702-4790
If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
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Data Source: ClinicalTrials.gov
Date Processed: March 22, 2011
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