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Study With AG-013736 Combined With Chemotherapy And Bevacizumab In Patients With Metastatic Colorectal Cancer - NCT00460603-47303(Clinical Trial 168260)



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City:  Muncie
State:  
IN
Zip Code: 47303
Conditions: Colorectal Neoplasms
Purpose: To determine the safety and efficacy of AG-013736 in combination with other standard of care medication in patients with first line metastatic colorectal cancer.
Study summary:
Criteria: Inclusion Criteria: - (Phase 1) Patients with any solid/GI tumor who have had no more than 1 previous chemotherapy for greater than 3 months prior to enrollment - (Phase 2) Patients with locally advanced or metastatic colorectal cancer (CRC) previously untreated with any systemic therapy. - Patients treated with adjuvant chemotherapy (with radiation) will be eligible if last treatment was > 12 months prior to enrollment, - Patients must have measurable disease by RECIST and if any history of hypertension, it must be controlled with medication. Exclusion Criteria: - Prior system therapy for advanced CRC (Ph 2 portion only) - Prior treatment with anti-angiogenesis agent such as bevacizumab or VEGF inhibitors. - Prior irradiation of greater than 25% of bone marrow (whole pelvis = 25%) - Prior radiation, major surgery, or investigational agent within 4 weeks of study entry except palliative radiotherapy to non-target, metastatic lesions. Minor surgeries should be completed > 2 weeks of enrollment and be fully recovered from any procedure.
Study is available at: Pfizer Investigational Site
Muncie, IN 47303
United States

Primary Contact:
Pfizer CT.gov Call Center
Phone: 1-800-718-1021
If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
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Data Source: ClinicalTrials.gov
Date Processed: March 22, 2011
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