Study With AG-013736 Combined With Chemotherapy And Bevacizumab In Patients With Metastatic Colorectal Cancer - NCT00460603-47303 (Clinical Trial 168260)
Permalink: http://www.ClinicalConnection.com/exp/ExpandedPatientViewStudy168260.aspx
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| City: |
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Muncie |
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State:
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IN |
| Zip Code: |
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47303 |
| Conditions: |
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Colorectal Neoplasms |
| Purpose: |
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To determine the safety and efficacy of AG-013736 in combination with other standard of care
medication in patients with first line metastatic colorectal cancer.
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| Study summary: |
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| Criteria: |
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Inclusion Criteria:
- (Phase 1) Patients with any solid/GI tumor who have had no more than 1 previous
chemotherapy for greater than 3 months prior to enrollment
- (Phase 2) Patients with locally advanced or metastatic colorectal cancer (CRC)
previously untreated with any systemic therapy.
- Patients treated with adjuvant chemotherapy (with radiation) will be eligible if last
treatment was > 12 months prior to enrollment,
- Patients must have measurable disease by RECIST and if any history of hypertension,
it must be controlled with medication.
Exclusion Criteria:
- Prior system therapy for advanced CRC (Ph 2 portion only)
- Prior treatment with anti-angiogenesis agent such as bevacizumab or VEGF inhibitors.
- Prior irradiation of greater than 25% of bone marrow (whole pelvis = 25%)
- Prior radiation, major surgery, or investigational agent within 4 weeks of study
entry except palliative radiotherapy to non-target, metastatic lesions. Minor
surgeries should be completed > 2 weeks of enrollment and be fully recovered from any
procedure. |
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| Study is available at: |
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Pfizer Investigational Site
Muncie, IN 47303
United States
Primary Contact:
Pfizer CT.gov Call Center
Phone: 1-800-718-1021 |
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If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
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| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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March 15, 2010 |
Modifications to
this listing: |
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Only selected fields are shown, please use the link
above to view all information about this clinical trial. |
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Clinical trials are medical research studies designed to test the safety and/or
effectiveness of new drugs, devices, or treatments in humans. These studies are
conducted worldwide for a range of conditions and illnesses. Learn more about
clinical research and participating in a study at
About Clinical Trials.
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