Risk-Group Classification of Patients With Newly Diagnosed Acute Lymphoblastic Leukemia - NCT00482352-Perth


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Risk-Group Classification of Patients With Newly Diagnosed Acute Lymphoblastic Leukemia - NCT00482352-Perth - 004 (Clinical Trial 171498)
Permalink: http://www.ClinicalConnection.com/exp/ExpandedPatientViewStudy171498.aspx

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City:

Perth

Country:

Australia

Conditions:

Leukemia

Purpose:

RATIONALE: Developing a risk-group classification guide may help doctors assign patients with newly diagnosed acute lymphoblastic leukemia to treatment clinical trials. PURPOSE: This clinical trial is studying risk-group classification of patients with newly diagnosed acute lymphoblastic leukemia.

Study summary:

OBJECTIVES: - Provide a classification guide that will organize the clinical and laboratory data necessary for assigning each patient with newly diagnosed acute lymphoblastic leukemia (ALL) to a specific treatment clinical trial. - Provide an administrative base to capture classification data for correlative studies accompanying current Children's Oncology Group (COG) ALL treatment clinical trials. - Provide a central reference guide for all required and research only ALL studies that will be conducted at local and reference laboratories. - Provide a mechanism for optional banking of leukemia and germline specimens for current and future research. OUTLINE: Patients undergo blood collection and bone marrow biopsies at baseline and at the end of induction therapy for immunophenotyping for marker identification; molecular testing for translocations; trisomy analysis by fluorescence in situ hybridization (FISH); and DNA ploidy. Immunophenotype results obtained on this study are used to determine the patient's assignment to specific treatment clinical trials (consistent with acute lymphoblastic leukemia). After completion of induction therapy, patients are followed once or twice annually.

Criteria:

DISEASE CHARACTERISTICS: - Newly diagnosed acute lymphoblastic leukemia, defined by any of the following: - At least 25% blasts in the bone marrow - Absolute blast count at least 10,000/mm^3, if bone marrow aspiration is not performed - No prior registration on this study PATIENT CHARACTERISTICS: Age - Under 31 Performance status - Not specified Life expectancy - Not specified Hematopoietic - Not specified Hepatic - Not specified Renal - Not specified PRIOR CONCURRENT THERAPY: Biologic therapy - Not specified Chemotherapy - Not specified Endocrine therapy - Not specified Radiotherapy - Not specified Surgery - Not specified

Study is available at:

Princess Margaret Hospital for Children
Perth
Australia

Primary Contact:
Catherine H. Cole
Phone: 011-6189340-8238

If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.

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Data Source:		ClinicalTrials.gov
Date Processed:		March 15, 2010
Modifications to this listing:		Only selected fields are shown, please use the link above to view all information about this clinical trial.

Clinical trials are medical research studies designed to test the safety and/or effectiveness of new drugs, devices, or treatments in humans. These studies are conducted worldwide for a range of conditions and illnesses. Learn more about clinical research and participating in a study at About Clinical Trials.


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