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View Clinical Trial (Medical Research Study)
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Chemotherapy-Induced Changes to Cognition and DNA in Breast Cancer Survivors - NCT00496613-11570 (Clinical Trial 175469)
Permalink: http://www.ClinicalConnection.com/exp/ExpandedPatientViewStudy175469.aspx
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| City: |
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Rockville Centre |
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State:
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NY |
| Zip Code: |
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11570 |
| Conditions: |
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Breast Cancer - Long-Term Survivors |
| Purpose: |
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The purpose of this study is to learn more about how chemotherapy affects an individual's
thinking abilities (cognition). Some research has shown that chemotherapy can cause changes
in cognition in breast cancer survivors. However, it is not clear why this change occurs. In
this study, the investigators will look to see if damage to DNA is related to these changes
in cognition. Specifically, the investigators want to see 1) if women who have been treated
with chemotherapy have more DNA damage than healthy women; and 2) if DNA damage is related
to cognitive problems in breast cancer survivors and healthy women.
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| Study summary: |
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The primary objective of this proposal is to obtain preliminary data regarding the
association between DNA damage and cognitive functioning in breast cancer survivors.
Specifically, we predict that:
1. Breast cancer survivors treated with chemotherapy and hormonal therapy will have higher
levels of DNA damage as measured by the Comet assay as compared to age and education
matched survivors treated with hormonal therapy only and healthy controls.
2. Survivors who meet criteria for cognitive impairment will have higher levels of DNA
damage as compared to cancer survivors who do not meet criteria for cognitive
impairment and healthy controls. |
| Criteria: |
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Inclusion Criteria:
- Breast cancer survivors (Stage I-III) 2-6 years post all cancer treatments, but
currently receiving hormone therapy.
- History of treatment with chemotherapy and/or hormonal therapy, or hormone therapy
only.
- No evidence of active/recurrent disease.
- Less than 70 years old at time of recruitment.
- Post-menopausal prior to initial treatment.
- In the judgment of the consenting professional, is able to provide informed consent.
- Patient is able to understand English, through verbal and written communication.
Exclusion Criteria:
- Recurrence of breast cancer or diagnosis of another cancer except basal cell
carcinoma.
- Exposure to chemotherapy or radiation therapy for any medical condition unrelated to
breast cancer.
- Neurobehavioral risk factors including history of neurological disorder, or moderate
to severe head trauma (loss of consciousness > 60 min or evidence of structural brain
changes on imaging).
- Neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease,
multiple sclerosis, etc.
- Self-reported sleep disorders that could influence cognitive functioning including
sleep apnea and chronic fatigue syndrome.
- Self-reported Axis I psychiatric disorder (DSM-IV), major affective disorder
(untreated), bipolar disorder, schizophrenia.
- Disorder (DSM-IV), major affective disorder (untreated), bipolar disorder,
schizophrenia.
- Male.
Healthy Control Inclusion Criteria:
- Have had no diagnosis of cancer except basal cell carcinoma.
- Less than 70 years old at time of recruitment.
- Post-menopausal.
- In the judgment of the consenting professional, is able to provide informed consent.
- Patient is able to understand English, through verbal and written communication
Healthy Control Exclusion Criteria:
- Exposure to chemotherapy or radiation therapy for any medical condition.
- Neurobehavioral risk factors including history of neurological disorder, or moderate
to severe head trauma (loss of consciousness > 60 min or evidence of structural brain
changes on imaging).
- Neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease,
multiple sclerosis etc.
- Self-reported sleep disorders that could influence cognitive functioning including
sleep apnea and chronic fatigue syndrome.
- Self-reported Axis I psychiatric disorder (DSM-IV), major affective disorder
(untreated), bipolar disorder, schizophrenia.
- Male. |
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| Study is available at: |
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Memorial Sloan-Kettering Cancer Center at Mercy Medical Center
Rockville Centre, NY 11570
United States
Primary Contact:
Tim Ahles, PhD
Email: ahlest@mskcc.org
Secondary Contact:
Tim Ahles, PhD
Email: ahlest@mskcc.org
Phone: 646-888-0048 |
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If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
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| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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March 15, 2010 |
Modifications to
this listing: |
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Only selected fields are shown, please use the link
above to view all information about this clinical trial. |
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Clinical trials are medical research studies designed to test the safety and/or
effectiveness of new drugs, devices, or treatments in humans. These studies are
conducted worldwide for a range of conditions and illnesses. Learn more about
clinical research and participating in a study at
About Clinical Trials.
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