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Diagnostic Investigation of Sudden Cardiac Event Risk - NCT00500708-55407(Clinical Trial 176796)



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City:  Minneapolis
State:  
MN
Zip Code: 55407
Conditions: Arrhythmia
Purpose: Heart failure (HF) affects 5 million Americans, with 500,000 new cases diagnosed and 250,000 deaths each year. The two major causes of morbidity and mortality in HF are pump failure and sudden, lethal ventricular arrhythmias, the latter of which accounts for 40-50% of HF deaths. Arrhythmias may be precipitated by a complex interaction of genetic and environmental factors. Establishing increased risk for arrhythmias before a severe life-threatening event is critically important. However, this remains a significant medical challenge. Several genetic mutations associated with rare, inherited arrhythmia disorders have been identified. The aim of this study is to identify novel genetic and other biological markers that distinguish patients at increased risk for lethal ventricular arrhythmias in a broader population.
Study summary:
Criteria: Inclusion Criteria: - ICD or CRT-D implanted for primary prevention - Left ventricular ejection fraction (LVEF) ≤ 50 % - Ability to collect clinical follow-up and endpoint information, including device interrogation data Exclusion Criteria: - Congenital heart disease - Known inherited arrhythmia disorder - Organ transplantation - Inability to give informed consent
Study is available at: Minneapolis Heart Institute and Foundation
Minneapolis, MN 55407
United States

Primary Contact:
Bradley Brown, MS
Email: bbrown@cardiodx.com
Phone: 650-475-2763
If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
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Data Source: ClinicalTrials.gov
Date Processed: March 22, 2011
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