Diagnostic Investigation of Sudden Cardiac Event Risk - NCT00500708-27705 (Clinical Trial 176797)
Permalink: http://www.ClinicalConnection.com/exp/ExpandedPatientViewStudy176797.aspx
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| City: |
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Durham |
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State:
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NC |
| Zip Code: |
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27705 |
| Conditions: |
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Arrhythmia |
| Purpose: |
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Heart failure (HF) affects 5 million Americans, with 500,000 new cases diagnosed and 250,000
deaths each year. The two major causes of morbidity and mortality in HF are pump failure
and sudden, lethal ventricular arrhythmias, the latter of which accounts for 40-50% of HF
deaths. Arrhythmias may be precipitated by a complex interaction of genetic and
environmental factors. Establishing increased risk for arrhythmias before a severe
life-threatening event is critically important. However, this remains a significant medical
challenge.
Several genetic mutations associated with rare, inherited arrhythmia disorders have been
identified. The aim of this study is to identify novel genetic and other biological markers
that distinguish patients at increased risk for lethal ventricular arrhythmias in a broader
population.
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| Study summary: |
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| Criteria: |
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Inclusion Criteria:
- ICD or CRT-D implanted for primary prevention
- Left ventricular ejection fraction (LVEF) ≤ 50 %
- Ability to collect clinical follow-up and endpoint information, including device
interrogation data
Exclusion Criteria:
- Congenital heart disease
- Known inherited arrhythmia disorder
- Organ transplantation
- Inability to give informed consent |
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| Study is available at: |
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Duke University Medical Center
Durham, NC 27705
United States
Primary Contact:
Amy J Sehnert, MD
Email: asehnert@cardiodx.com
Phone: 650-475-2705 |
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If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
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| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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March 15, 2010 |
Modifications to
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above to view all information about this clinical trial. |
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Clinical trials are medical research studies designed to test the safety and/or
effectiveness of new drugs, devices, or treatments in humans. These studies are
conducted worldwide for a range of conditions and illnesses. Learn more about
clinical research and participating in a study at
About Clinical Trials.
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