View Clinical Trial (Medical Research Study)
Mechanisms of Diabetes Control After Weight Loss Surgery - NCT00571220-10025(Clinical Trial 194159)
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New York |
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State:
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NY |
| Zip Code: |
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10025 |
| Conditions: |
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Surgical Condition Before and After Gastric Bypass Surgery - Diet Condition: Before and After a Weight Loss Equivalent to What Patients Lose 1 Month After GBP 9approximately 10kg) |
| Purpose: |
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Obesity and type 2 diabetes (T2DM) are increasing in the US. One third of patients seeking
bariatric surgery have T2DM. Although all surgeries result in significant weight loss and
often 'cure' the T2DM, the rapid onset and the magnitude of the benefits of gastric bypass
(GBP) on T2DM has thus far baffled clinical scientists. Limited data suggest that the
improvement in T2DM after GBP occurs very rapidly, and may not be wholly accounted for by
weight loss. Secretion of incretins (gut peptides secreted in response to meals which
enhance insulin secretion) is impaired in T2DM and improves after GBP, possibly due to the
specific anatomical changes after this surgery. While some determinants of impaired insulin
secretion, such as glucotoxicity, improve equally after diet or surgical weight loss, the
improvement in the incretin effect after GBP might be specific to this surgery. The AIM of
this study is to determine whether the magnitude of the incretin effect on insulin secretion
is greater after GBP than after an equivalent diet-induced weight loss. We will compare, in
obese patients with diabetes, randomized to very low calorie diet or to GBP, the effect of
an equivalent weight loss on the incretin effect (difference in insulin secretion after
comparable oral and intravenous (IV) glucose loads). As more obese diabetic patients
undergo GBP, understanding the mechanisms that produce improvement in their diabetes is
increasingly important.
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| Study summary: |
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| Criteria: |
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Inclusion Criteria:
- morbidly obese with type 2 diabetes candidates and being evaluated at our instituion
for bariatric surgery (group1); morbidly obese patients with type 2 diabetes who want
to lsoe weight by diet.
Exclusion Criteria:
- any condition that would be contra-indicated for bariatric surgery (ex:unstable
angina)
- diabetes treated by insulin, TZD, exenatide, DPP-IV inhibitors
- HbA1C > 8% |
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If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
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| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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January 5, 2011 |
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