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Mechanism of Action of Fluticasone Furoate in Childhood Obstructive Sleep Apnea Syndrome - NCT00603044-60637(Clinical Trial 200713)



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City:  Chicago
State:  
IL
Zip Code: 60637
Conditions: Childhood Obstructive Sleep Apnea Syndrome (OSAS)
Purpose: The purpose of this research is to find out how a nasal spray (fluticasone furoate), sometimes given to children with obstructive sleep apnea syndrome (OSAS), works on certain cells within a child's adenoids. We hypothesize that intranasal steroids lead to an upregulation of T regulatory cells in the adenoid tissues of children with OSAS. This will result in a local reduction in inflammation and edema explaining the improvement in OSAS.
Study summary:
Criteria: Inclusion Criteria: - Age: between 2 and 12 years - Polysomnogram results showing AHI >5/hr irrespective of saturations - No other significant medical problems except well controlled asthma - No chronic medication intake except bronchodilators and leukotriene receptor antagonists - No systemic steroids within the past month - No intranasal steroids within the past 2 weeks Exclusion Criteria: - Patients with OSAS who are overweight (BMI>95th percentile for age) or who have neurological or craniofacial abnormalities as these tend to have OSAS related to these factors per se. - Females of the specified age group who have already had their first period.
Study is available at: University of Chicago
Chicago, IL 60637
United States

Primary Contact:
Fuad M Baroody, MD
Email: fbaroody@surgery.bsd.uchicago.edu
Phone: 773-702-5889
If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
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Data Source: ClinicalTrials.gov
Date Processed: March 22, 2011
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