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Treatment of Postoperative Pain After Total Knee Arthroplasy Using Intravenous Lidocaine Infusion - NCT00616850-92354(Clinical Trial 203037)



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City:  Loma Linda
State:  
CA
Zip Code: 92354
Conditions: Total Knee Arthroplasty
Purpose: Total knee replacement is often associated with severe postoperative pain, especially in the first 24 hours. Patient controlled analgesia (PCA) and continuous femoral block with PCA are commonly used to treat postoperative pain after total knee arthroplasty. However, PCAs use opioids. Opioids are excellent painkillers but their use is hampered by side effects such as nausea, vomiting, bowel dysfunction, urinary retention, pruritus, sedation and respiratory depression. We propose to test the hypothesis that adding a low dose lidocaine infusion to PCAs will lower the amount of opioids that these patients receive, thereby improving patient safety while still providing adequate analgesia. In addition, continuous femoral block has been shown to provide superior postoperative pain control when compared to morphine PCA. Therefore, postoperative pain levels of study subjects will be compared to those subjects who receive a combination of a continuous femoral block catheter with a PCA.
Study summary:
Criteria: Inclusion Criteria: 1. Undergoing a total knee arthroplasty 2. Be American Society of Anesthesiologist physical status 1,2, or 3 3. Be willing and capable of providing informed consent 4. Be English speaking Exclusion Criteria: 1. Age greater than 80 years old or younger than 18 years old 2. Congestive hear failure 3. Hepatic insufficiency 4. Neurological disorders 5. Psychiatric disorders 6. Steroid treatment 7. History of atrial fibrillation 8. Chronic pain disorder with opioid treatment
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Data Source: ClinicalTrials.gov
Date Processed: April 13, 2010
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