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Energy Expenditure & Activity During & After Exercise-Induced Weight Loss - NCT00622310-80045(Clinical Trial 204001)



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City:  Aurora
State:  
CO
Zip Code: 80045
Conditions: Obesity
Purpose: This project is aimed at determining whether an exercise-based weight loss intervention causes a compensation in some component of energy expenditure such that the increase in measured energy expenditure is less than the added exercise. The study will compare two separate exercise interventions to determine if this is influenced by exercise intensity.
Study summary: The primary aim of this proposed study is to determine how total daily activity thermogenesis (TDAT) and total daily energy expenditure (TDEE) are regulated in obese humans attempting to lose weight and maintain weight loss through exercise. Two exercise interventions will be compared; a structured aerobic exercise program and a walking program. EAT will be verified, and NEAT, TDAT, and TDEE will be measured using state-of-the-art technologies. Subjects will be studied during a 6 month intervention period and then during a 6 month follow-up period. It is hypothesized that the walking program will have more favorable effects on TDAT and TDEE during both the intervention and follow-up periods. If our hypotheses are correct, then data from the proposed study could be used to improve the effectiveness of exercise-based weight loss and weight loss maintenance programs.
Criteria: Inclusion Criteria - Body mass index (BMI) 30-35.0 kg/m2 - Age 18-45 years - Weight stable (<2 kg weight fluctuation during previous 6 months) - No regular exercise (> 1 bout of exercise/wk or participation in any sporting activities > 1 hr/wk) - No self-report of acute or chronic disease (diabetes, heart diseases, and joint problems in particular) - No current use of prescribed medications - No plans to relocate within the next year - No plans for extended travel (> 1 week) within the next 6 months - No tobacco use - For females - No evidence of amenorrhea (Regular menstrual cycles of 21-35 days) - Pre-menopausal status (self-report, to be confirmed during screening) - Pregnancy or lactating within the past year - No pregnancy or planned pregnancies; sexually active women of childbearing potential may be enrolled if they have had a tubal ligation or use one of the following means of contraception: condom, diaphragm, oral or implanted contraceptives, or intrauterine device. Women in exclusive relationships with male partners who have had a successful vasectomy will not be required to use any additional means of birth control.
Study is available at: University of Colorado, School of Medicine
Aurora, CO 80045
United States

Primary Contact:
Edward L Melanson
Email: EXWTLOSS@uchsc.edu
Phone: 303-315-4087

Secondary Contact:
Edward L Melanson
Email: EXWTLOSS@uchsc.edu
Phone: (303) 315-4087
If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
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Data Source: ClinicalTrials.gov
Date Processed: March 22, 2011
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