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Genetics of Polycystic Ovary Syndrome - NCT00647335-19104(Clinical Trial 212582)



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City:  Philadelphia
State:  
PA
Zip Code: 19104
Conditions: PCOS
Purpose: The purpose of this study is to look at genes (DNA) and how they affect health and disease. Genes are the instruction manual for the body. The genes you get from your parents decide what you look like and how your body behaves. They can also tell us a person's risk for certain diseases and how they will respond to treatment. We will collect a saliva sample for genetic research
Study summary: Polycystic ovary syndrome (PCOS) is a common endocrine disorder of women, characterized by elevated levels of male hormones, absent menstruation, infrequent or very light menstruation, and reduced ability to reproduce. Genetic factors likely contribute to the etiology of PCOS, but no genes have been identified with certainty. The findings from these studies will enhance our understanding of the genetics of PCOS, a major contributor to female infertility. Better knowledge of "PCOS genes" will also help in predicting responses to treatments for infertility, insulin resistance, and other aspects of the disease. Women with PCOS may be eligible to participate in this study if they are between the ages of 18 and 50 and have two living biological parents who are also willing to participate. Study participation involves telephone screening and consent and home collection by subjects (probands) and their parents of sputum (saliva) in a provided container. Specimen containers and signed consent forms will be returned to the study site by mail. The major goal of this research project, the identification of genes contributing to PCOS, will provide basic understanding of the genotype-phenotype relationships that contribute to features of PCOS. Knowledge of "PCOS genes" would assist physicians in predicting and assessing responses to interventions that promote fertility, improve insulin sensitivity, and treat other aspects of the disease.
Criteria: Inclusion Criteria: - Diagnosis of PCOS - Both biological parents alive - Yes to both answers and parents willing to participate Exclusion Criteria: - Healthy women
Study is available at: University of Pennsylvania
Philadelphia, PA 19104
United States

Primary Contact:
Linda R Martino, CRNP
Email: lmartino@obgyn.upenn.edu
Phone: 215-615-3664

Secondary Contact:
Linda R Martino, CRNP
Email: lmartino@obgyn.upenn.edu
Phone: (215) 615-3664
If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
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Data Source: ClinicalTrials.gov
Date Processed: March 22, 2011
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