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View Clinical Trial (Medical Research Study)
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Contingency Management and Pharmacotherapy for Smoking Cessation - NCT00683280-06030 (Clinical Trial 222631)
Permalink: http://www.ClinicalConnection.com/exp/ExpandedPatientViewStudy222631.aspx
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| City: |
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Farmington |
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State:
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CT |
| Zip Code: |
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06030 |
| Conditions: |
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Cigarette Smoking |
| Purpose: |
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In total, 70 smokers will be randomized to: varenicline alone (an FDA-approved smoking
cessation medication) or varenicline plus contingency management (CM) (a behavioral
procedure with rewards for target behaviors, like smoking abstinence). Patients in both
conditions will receive varenicline for 12 weeks with standard smoking cessation therapy and
regular breath and urine sample monitoring for smoking. Patients assigned to CM will earn
chances to win prizes for each breath sample that tests negative for smoking, and urine
samples that test negative for smoking will result in even greater chances for prizes. More
CM patients are expected to achieve and maintain abstinence than patients receiving
varenicline alone.
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| Study summary: |
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| Criteria: |
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Inclusion Criteria:
- smoke >10 cigarettes/day, with no abstinent period exceeding 3 months in past year
- expired CO of >8 ppm
- self-reported desire to stop smoking
- >18 years of age
- resting systolic BP<160 mmHg and diastolic BP<100 mmHg and otherwise in good health
- if on antihypertensive medication, have not changed medications in the past month and
do not intend to change in next 3 months
- English speaking
Exclusion Criteria:
- receipt of smoking cessation treatment (behavioral or pharmacological) in past month
- serious or unstable medical disease in past 6 months, including myocardial
infarction, cancer, congestive heart failure, kidney failure, stroke, or seizures
- evidence or history of allergic reactions contraindicating varenicline or clinically
significant laboratory or electrocardiographic (ECG) abnormalities
- breastfeeding, pregnant or not using effective contraception if a woman of
childbearing potential
- arm circumference of >42 cm
- serious psychiatric illness in past 6 months (e.g., schizophrenia, psychosis, suicide
risk, drug or alcohol dependence other than nicotine)
- use of tobacco containing products other than cigarettes in past month and do not
agree to abstain from use of these products during study participation
- ongoing use of any of the following medications: nicotine replacement therapies,
monoamine oxidase inhibitors, antipsychotics, mood stabilizers, or naltrexone
- in recovery for pathological gambling, due to potential similarity with prize CM,
although no increases in gambling have been noted |
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| Study is available at: |
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University of Connecticut Health Center
Farmington, CT 06030
United States
Primary Contact:
Ellen M Ciesielski, B.A.
Email: eciesielski@uchc.edu
Phone: 860-679-4556 |
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If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
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| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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March 15, 2010 |
Modifications to
this listing: |
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Only selected fields are shown, please use the link
above to view all information about this clinical trial. |
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Clinical trials are medical research studies designed to test the safety and/or
effectiveness of new drugs, devices, or treatments in humans. These studies are
conducted worldwide for a range of conditions and illnesses. Learn more about
clinical research and participating in a study at
About Clinical Trials.
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