Magnetoencephalographic (MEG) Localization of Ramelteons Effects on Brain Function and Cortical Arousal in Insomnia - NCT00688025-48202 (Clinical Trial 223560)


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Magnetoencephalographic (MEG) Localization of Ramelteons Effects on Brain Function and Cortical Arousal in Insomnia - NCT00688025-48202 (Clinical Trial 223560)
Permalink: http://www.ClinicalConnection.com/exp/ExpandedPatientViewStudy223560.aspx

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City:

Detroit

State:

Zip Code:

48202

Conditions:

Insomnia

Purpose:

The present protocol will utilize simultaneous recording of brain activity during attention and memory tasks in insomnia participants after ramelteon vs. zolpidem vs. placebo administration. The investigators hypothesize that amplitudes of associated with memory will be unchanged by ramelteon, whereas zolpidem will significantly reduce brain activity associated with stimulus processing as evidenced by abnormal reduction in the amplitude of specific brain regions relative to placebo.

Study summary:

The proposed research has two specific aims: 1) demonstrate that ramelteon has no effect on event related potential components that reflect basic sensory processes (P1 and N1), and will not impair attention and memory processes, whereas the benzodiazepine receptor agonist zolpidem will significantly reduce (relative to placebo) the amplitude of these event related potential components throughout the cerebral cortex and 2) show that ramelteon reduces the abnormal hyperarousal in insomnia as reflected through a reduction in the contingent negative variation component of the event related potential across frontal and parietal brain regions.

Criteria:

Inclusion Criteria: - Healthy individuals with no secondary condition to insomnia. Exclusion Criteria: - Healthy individuals with no insomnia.

Study is available at:

Henry Ford Hospital Sleep Disorders & Research Center
Detroit, MI 48202
United States

Primary Contact:
Christopher Drake, Ph.D.
Phone: 313-916-4455

If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.

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Data Source:		ClinicalTrials.gov
Date Processed:		March 15, 2010
Modifications to this listing:		Only selected fields are shown, please use the link above to view all information about this clinical trial.

Clinical trials are medical research studies designed to test the safety and/or effectiveness of new drugs, devices, or treatments in humans. These studies are conducted worldwide for a range of conditions and illnesses. Learn more about clinical research and participating in a study at About Clinical Trials.


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