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Effect of Losartan on Chronic Obstructive Pulmonary Disease (COPD) - NCT00720044-21205(Clinical Trial 232575)



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City:  Baltimore
State:  
MD
Zip Code: 21205
Conditions: COPD - Emphysema - Chronic Obstructive Pulmonary Disease - Chronic Bronchitis
Purpose: Losartan, an angiotensin receptor blocker, has been effective in preventing the development of emphysema and lung inflammation in animal models of COPD. Moreover, there is epidemiologic evidence that suggests that this drug may be effective in reducing COPD morbidity and mortality. This study will provide treatment with either losartan or placebo for a period of 12 months to determine whether there is progression of COPD as measured by high-resolution CT scans, lung function, or blood tests for inflammation.
Study summary:
Criteria: Inclusion Criteria: - Evidence of COPD by pulmonary function testing Exclusion Criteria: - Clinical indication for angiotensin receptor blockers or ACE inhibitors - Significant kidney disease or heart disease - History of intolerance to losartan or similar drugs
Study is available at: Johns Hopkins Hospital
Baltimore, MD 21205
United States

Primary Contact:
Teresa Concordia
Email: tconcor1@jhmi.edu
Phone: 410-550-2449

Secondary Contact:
Marie Daniel
Email: mdaniel@jhmi.edu
Phone: 410 550-0800
If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
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Data Source: ClinicalTrials.gov
Date Processed: March 22, 2011
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