In Vivo Anatomy, Physiology, Mechanics and Function of the Lower Esophageal Sphincter - NCT00737802-19040(Clinical Trial 237643)
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Philadelphia |
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State:
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PA |
| Zip Code: |
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19040 |
| Conditions: |
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GERD |
| Purpose: |
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The purpose of this study is:
- To study the components of the gastroesophageal junction high-pressure zone
individually and as a group, by pharmacologically eliminating or accentuating the
pressure profile generated by the smooth muscle components.
- To differentiate the gastric sling fibers from the clasp fibers based on the spatial
orientation of these muscle groups.
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| Study summary: |
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| Criteria: |
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Inclusion Criteria:
Inclusion criteria for GERD patients are:
- Symptomatic heartburn
- Regurgitation
- Chest pain or water brash
Exclusion Criteria:
Exclusion criteria for normal volunteers include:
- Medications-Subjects on any medication which could effect the gastroesophageal
junction high-pressure zone will be excluded, this includes use of antacids, H2
blockers, proton pump inhibitors, prokinetic agents, erythromycin type antibiotics
and anticholinergics.
- GI symptoms, conditions and disorders
In addition exclusion criteria will include a history of:
- Esophagitis
- Gastrointestinal symptoms such as abdominal pain
- Heartburn
- Reflux
- Regurgitation
- Chest pain
- Difficulty swallowing
- Pain on swallowing
- Dysphagia
- Abdominal surgery involving the stomach or esophagus
- Nausea or vomiting
- Diabetes
- Scleroderma
- Esophageal motility disorders
- Non cardiac chest pain
- Achalasia and current pregnancy. |
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| Study is available at: |
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Temple University Hospital
Philadelphia, PA 19040
United States
Primary Contact:
Larry Miller, M.D.
Email: vivi@temple.edu
Phone: 215-707-6922
Secondary Contact:
Larry Miller, M.D.
Email: vivi@temple.edu
Phone: 215-707-6922 |
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If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
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| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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March 22, 2011 |
Modifications to
this listing: |
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Only selected fields are shown, please use the link
above to view all information about this clinical trial. |
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