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Impulsivity, Neural Deficits and Cocaine Addiction - NCT00744601-75390(Clinical Trial 240064)



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City:  Dallas
State:  
TX
Zip Code: 75390
Conditions: Cocaine Dependence
Purpose: The purpose of this study is to assess neurocognitive and associated neural regions/circuitry disruptions relevant to impulsive relapse in cocaine-addicted subjects, and the relationship of the cognitive and neural mechanisms of impulsivity/decision-making to relapse style.
Study summary: This study is designed to explore putative differences in impulsive behaviors and decision making in cocaine-addicted and healthy control subjects using functional magnetic resonance imaging (fMRI), single photon emission tomography (SPECT), and neurocognitive tasks. We predict that cocaine-addicted subjects will demonstrate neurocognitive and neural alterations in measures of impulsivity and decision-making when compared to healthy controls. That is, cocaine-addicted subjects will show both decreased activation and decreased resting measures of regional cerebral blood flow (rCBF) of the brain structures associated with impulsivity and decision-making. Furthermore, neurocognitive and neural deficits associated with impulsivity and decision-making will be associated with each other and with measures indicative of an impulsive relapse and altered decision making.
Criteria: Inclusion Criteria: - Cocaine-dependence (patient population) or no cocaine-dependence (control population). Exclusion Criteria: - Other medical or psychiatric disorders that may effect neural functioning. - Medications that may effect neural functioning.
Study is available at: UT Southwestern Medical Center at Dallas, Divison on Addictions
Dallas, TX 75390
United States

Primary Contact:
Bryon Adinoff, MD
Email: bryon.adinoff@utsouthwestern.edu
Phone: 214-645-6975

Secondary Contact:
Bryon Adinoff, MD
Email: bryon.adinoff@utsouthwestern.edu
Phone: 214-645-6975
If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
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Data Source: ClinicalTrials.gov
Date Processed: March 22, 2011
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