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Cortisol Augmentation of Prolonged Exposure Therapy - NCT00751855-10468(Clinical Trial 241717)



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City:  Bronx
State:  
NY
Zip Code: 10468
Conditions: PTSD
Purpose: This study seeks to examine the efficacy of hydrocortisone administration in the augmentation of the therapeutic effects of Prolonged Exposure (PE) therapy, an empirically tested treatment shown to be effective in the the treatment of posttraumatic stress disorder (PTSD). The augmentation builds on both the translation of neuroscience findings demonstrating the effects of glucocorticoids (GCs) on learning, and on empirical clinical findings from other investigators demonstrating beneficial effects of GCs in reducing traumatic memories in trauma-exposed persons.
Study summary:
Criteria: Inclusion Criteria: - Veterans who experienced a criterion A trauma while deployed, and a current diagnosis of PTSD with a minimum of 6 months - Capable of understanding, reading and writing English Exclusion Criteria: - Incapable and/or unwilling to provide written informed consent prior to participation - Unwilling and/or unable to discontinue current psychotherapy - Regular use of psychotropic medication including antidepressants, benzodiazepines, lithium, mood stabilizers, over-the-counter supplements (melatonin, kava-kava, ephedra) - Regular use of oral or inhaled steroids - Significant illness (e.g., type I or II diabetes requiring the use of insulin, HIV, AIDS, seizure disorder, anemia, Lyme disease, etc.) - The veteran, the veteran's physician, or the study physician think that the veteran's clinical state necessitates the prompt initiation of pharmacotherapy or other treatment that would preclude involvement in the study - Morbid obesity (VMI > 40) - Clinically significant laboratory abnormalities as determine during medical clearance procedures - For women, a positive pregnancy test - Heavy smoking (more than 2 packs a day) - Substance and/or alcohol abuse and/or dependence within the previous 6 months - Response of 3 or 4 on the suicidality items of the HDRS or an assessed serious suicide risk - Current psychosocial problems that might interfere with treatment compliance - A lifetime history of schizophrenia, schizoaffective disorder, bipolar disorder, obsessive compulsive disorder or PTSD due to a trauma not sustained in the combat theater
Study is available at: James J. Peters Veterans Affairs Medical Center
Bronx, NY 10468
United States

Primary Contact:
Rachel Yehuda, PhD
Email: rachel.yehuda@va.gov
Phone: 718-741-4000
If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
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Data Source: ClinicalTrials.gov
Date Processed: March 22, 2011
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