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Compromised Microcirculation in Women With Polycystic Ovary Syndrome - NCT00757185-06520(Clinical Trial 242808)



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City:  New Haven
State:  
CT
Zip Code: 06520
Conditions: Polycystic Ovary Syndrome
Purpose: The scientific aims of the study are to determine how peripheral microcirculatory responsiveness is altered in obese women with Polycystic Ovary Syndrome (PCOS) during local heating and to determine the mechanism for testosterone effects on peripheral microcirculatory responsiveness in women with PCOS.
Study summary: In these studies, we propose to use the skin as a relatively non-invasive model to examine cardiovascular and endothelial function in obese women with and without PCOS. Data have indicated an important role for testosterone in influencing the peripheral microcirculation. While testosterone can lead to vasodilation in the peripheral microcirculation in both men and in women without PCOS, testosterone appears to induce vasoconstriction in women with PCOS. The differential response between women with and without PCOS, and between men and women may be the result of differential ET-1 actions in the vessel, and regulated by the receptor subtype is involved in these actions.
Criteria: Inclusion Criteria: - Obese women (18-35) years with and without PCOS Exclusion Criteria: - Conditions that would preclude safe use of hormones
Study is available at: John B. Pierce Laboratory
New Haven, CT 06520
United States

Primary Contact:
Nina Stachenfeld, PhD
Email: nstach@jbpierce.org
Phone: 203 562-9901
If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
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Data Source: ClinicalTrials.gov
Date Processed: March 22, 2011
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