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The Role of Parathyroid Hormone (PTH) in Low Bone Mass in Anorexia Nervosa - NCT00759772-02114(Clinical Trial 243341)



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City:  Boston
State:  
MA
Zip Code: 02114
Conditions: Anorexia Nervosa - Osteoporosis
Purpose: Decreased bone strength is a common and serious medical problem present in many women with anorexia nervosa, or disordered eating. Women with decreased bone strength are more likely to suffer broken bones than women with normal bone strength. We are investigating whether a hormone that is naturally produced by the human body -- called parathyroid hormone (PTH) -- can help strengthen the bones of women with anorexia nervosa.
Study summary: Anorexia Nervosa (AN) affects 0.5-1% of college-age women in the US and is associated with a number of significant medical conditions including bone loss. A majority of women with AN have bone loss and 50% have bone mineral density (BMD) measurements greater than 2 standard deviations below normative means. Bone loss in AN is characterized by a decrease in bone formation, therefore therapy with an anabolic agent may be an effective treatment approach. In a randomized, single-blinded, placebo-controlled trial, we will study the effects of PTH on low bone mass in AN, specifically looking at the effects of PTH on bone mineral density, as measured by DXA, and trabecular bone micro architecture, as measured by Xtreme CT.
Criteria: Inclusion Criteria: - Anorexia Nervosa - Women, age 35-70 years - Osteoporosis or history of clinical fractures (spine, wrist, hip or ribs) Exclusion Criteria: - Diseases known to affect bone metabolism - Hyperparathyroidism - Medications known to affect bone metabolism in last 12 weeks (or bisphosphonate use in last 1 year) - Pregnant and/or breastfeeding - Diabetes mellitus - History of malignancy involving or affecting the bone, any active malignancy, and/or radiation therapy to the bone - Fractures of a bone other than a finger or toe in last 1 year
Study is available at: Massachusetts General Hospital
Boston, MA 02114
United States

Primary Contact:
Pouneh K Fazeli, MD
Email: pkfazeli@partners.org
Phone: 617-726-1347

Secondary Contact:
Pouneh K Fazeli, MD
Email: pkfazeli@partners.org
Phone: 617-726-1347
If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
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Data Source: ClinicalTrials.gov
Date Processed: March 22, 2011
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