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View Clinical Trial (Medical Research Study)
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Reducing Alcohol Use & Post-traumatic Stress Disorder (PTSD) With Cognitive Restructuring & Experiential Acceptance - NCT00760994-98108 (Clinical Trial 243491)
Permalink: http://www.ClinicalConnection.com/exp/ExpandedPatientViewStudy243491.aspx
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| City: |
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Seattle |
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State:
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WA |
| Zip Code: |
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98108 |
| Conditions: |
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Alcoholism - Stress Disorders, Post-Traumatic |
| Purpose: |
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The purpose of this study is to determine whether an experiential acceptance therapy
intervention is effective in the treatment of alcohol dependency and post-traumatic stress
disorder (PTSD) symptoms in individuals who suffer from PTSD.
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| Study summary: |
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Alcohol dependence (AD) afflicts nearly 14% of the population (Kessler et al., 1994; Kessler
et al., 1997; Regier et al., 1990), and has a chronic and relapsing course (Brownell,
Marlatt, Litchenstein, & Wilson, 1986). Negative emotional states have consistently been
found to maintain alcohol use disorders (AUDs; Cooney, Litt, Morse, Bauer, & Gaupp, 1997;
Litt, Cooney, Kadden, & Gaupp, 1990; Rubonis et al., 1994) and increase the risk of relapse
following AUD treatment (Cooney et al., 1997). This relationship is particularly robust
among individuals with co-morbid psychiatric disorders, such as posttraumatic stress
disorder (PTSD; Coffey et al., 2002; Sharkansy, Brief, Peirce, Meehan, & Mannix, 1999; Tate,
Brown, Unrod, & Ramo, 2004; Waldrop, Back, Verduin, & Brady, in press). Likewise, alcohol
use may be maintained by a desire to facilitate or prolong positive emotional states
(Cooper, Frone, Russell, & Mudar, 1992; Simpson, 2003).
Many psychological interventions for AUDs, most notably the majority of cognitive-behavioral
treatment (CBT) packages, have thus focused on the development of coping skills to prevent
relapse in response to such triggers, and have been demonstrated to be at least moderately
effective in promoting abstinence (Miller & Wilbourne, 2002). However, attempts to specify
the active ingredients of CBT for AD have been disappointing and most studies examining
potential mechanisms of change have failed to find the expected relationships (Longabaugh et
al., 2005; Morgenstern & Longabaugh, 2000). The lack of empirical evidence substantiating
coping skills as a mechanism of change for CBT (Morgenstern & Longabaugh, 2000) may be due,
in part, to the lack of specificity in coping skill interventions. Broadly speaking, two
primary foci of coping skill interventions for AUD are 1) increasing cognitive techniques
focused on challenging and changing thought patterns, or 2) increasing experiential
acceptance by fostering an accepting stance towards internal states, such as through "urge
surfing" (Kadden et al., 1992). These two coping skill approaches (cognitive restructuring
and experiential acceptance) likely lead to reduced alcohol use through different pathways.
Theoretically, experiential acceptance approaches suggest that the mechanism of change in
decreasing alcohol use is increased willingness toward internal experience (e.g., emotions,
thoughts, sensations), whereas cognitive restructuring approaches suggest that decreased
alcohol use results from decreases in negative appraisals brought about by challenging and
changing thought patterns. However, this has yet to be systematically evaluated. |
| Criteria: |
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Inclusion Criteria:
- age at least 18 years
- current DSM-IV diagnosis of alcohol dependence (AD) with some alcohol use in the last
month
- current DSM-IV diagnosis of post-traumatic stress disorder (PTSD)
- capacity to provide informed consent
- English fluency
- no planned absences that they would be unable to complete 6 weeks of daily monitoring
and study sessions
- access to a telephone
- desire to decrease or stop alcohol drinking behavior
Exclusion Criteria:
- a history of delirium tremens
- seizures, in order to ensure that participants will be medically safe to decrease
alcohol use
- opiate abuse or dependence use or chronic treatment with any opioid- containing
medications during the previous month
- currently taking or planning to start taking either antabuse or naltrexone (due to
their pharmacological impact on alcohol cravings and use)
- exhibits signs or symptoms of alcohol withdrawal at the time of initial consent
- acutely suicidal with intent/plan or present an imminent danger to others
- a current psychotic disorder
For ethical reasons and because of the preliminary nature of this study, participants may
be in ongoing substance abuse or mental health treatment (MH) or may initiate counseling
or medications (other than those noted in exclusion criteria) during the course of the
study. Mental health treatment involvement will be used as a covariate if it is related to
study dependent variables. |
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| Study is available at: |
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VA Puget Sound Health Care System
Seattle, WA 98108
United States
Primary Contact:
Christina F Rosenthal, B.S.
Phone: 206-277-6793
Secondary Contact:
Christina F Rosenthal, B.S.
Phone: 206-277-6793 |
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If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
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| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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March 16, 2010 |
Modifications to
this listing: |
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Only selected fields are shown, please use the link
above to view all information about this clinical trial. |
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Clinical trials are medical research studies designed to test the safety and/or
effectiveness of new drugs, devices, or treatments in humans. These studies are
conducted worldwide for a range of conditions and illnesses. Learn more about
clinical research and participating in a study at
About Clinical Trials.
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