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View Clinical Trial (Medical Research Study)
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Characterization of Brachial Arterial t-PA Release, Endothelial Function, Obesity and Inflammation - NCT00780481-37232 (Clinical Trial 249361)
Permalink: http://www.ClinicalConnection.com/exp/ExpandedPatientViewStudy249361.aspx
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| City: |
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Nashville |
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State:
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TN |
| Zip Code: |
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37232 |
| Conditions: |
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Obesity |
| Purpose: |
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T-PA release is impaired in obese subjects. In order to have a better mechanistic
understanding of t-PA release, we will compare t-PA release to Flow Mediated Vasodilation,
Radial Artery Tonometry, and other markers of endothelial function and oxidative stress.
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| Study summary: |
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| Criteria: |
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Inclusion criteria:
1. Adults 18 years and greater
2. Healthy
Exclusion criteria:
1. PVC < 30
2. Hypertensive subjects on ACE inhibitors
3. Pregnant or nursing mothers
4. Diabetic with HbA1C > 7.5 or stigmata of end organ damage (neuropathy, retinopathy,
nephropathy, cardiomyopathy)
5. Cholesterol > 30 mg/dL above NCEP accepted level based on cardiac risk.
6. Triglycerides > 200
7. Previously diagnosed obstructive coronary artery disease, myocardial infarction or
left ventricular dysfunction (with or without a history of congestive heart failure)
8. Renal insufficiency (Creatinine ≥ 1.5 mg/dl)
9. History of cerebrovascular disease
10. Any chronic inflammatory disease (rheumatologic, inflammatory bowel disease, etc)
11. Uncontrolled Stage 2 Hypertension (160/100 mmHg), or end organ damage due to
hypertension (left ventricular hypertrophy, atrial fibrillation, hematuria, renal
insufficiency, prior cerebrovascular disease).
12. Angiotensin converting enzyme inhibitor use
13. Coagulopathy (INR ≥ 1.5, PTT ≥ 1.5 x control)
14. Other chronic medical illnesses at the discretion of the investigators |
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| Study is available at: |
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Vanderbilt University Medical Center
Nashville, TN 37232
United States
Primary Contact:
James AS Muldowney, III, MD
Email: james.muldowney@vanderbilt.edu
Phone: 615-936-1750
Secondary Contact:
James AS Muldowney, III, MD
Email: james.muldowney@vanderbilt.edu
Phone: 615-936-1720 |
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If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
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| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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November 16, 2009 |
Modifications to
this listing: |
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Only selected fields are shown, please use the link
above to view all information about this clinical trial. |
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Clinical trials are medical research studies designed to test the safety and/or
effectiveness of new drugs, devices, or treatments in humans. These studies are
conducted worldwide for a range of conditions and illnesses. Learn more about
clinical research and participating in a study at
About Clinical Trials.
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