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Bipolar Disorder in Late Life - NCT00787930-27701(Clinical Trial 251931)



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City:  Durham
State:  
NC
Zip Code: 27701
Conditions: Bipolar Disorder
Purpose: The purpose of this study is to look at certain structural changes in the brain in people with bipolar disorder or those with a history of Bipolar disorder. Also collecting a blood sample for genetic testing as relationship of genetics and changes in the brain.
Study summary: Individuals with bipolar disorder or those with a history of bipolar disorder may have certain structural changes in their brain. The purpose of this study is to look at those changes, as well as the assessment of risk factors for bipolar disorders, involving both social and psychological aspects of behavior, age, education, marital relations, nutrition, physical activity, etc., compared with persons not having bipolar disorder. These changes in the brain will be measured by Magnetic Resonance Imaging (MRI). A blood sample for genetic testing as we will be studying the relationship of genetics and changes in the structure the brain as evidenced by persons having MRI hyperintensities.
Criteria: Inclusion Criteria: 1. DSM-IV diagnosis of bipolar Disorder, Manic and mixed episodes. 2. 18 years of age and older, male or female, any race. Half the subjects will be above age 50. 3. Capacity to give informed consent and follow study procedures. Exclusion Criteria: 1. History of alcohol/drug dependence 2. Any metal or pacemaker in the body which precludes MRI 3. Pregnancy 4. Dementia or other primary psychiatric disorders including substance abuse/dependence, anxiety disorders, schizophrenia 5. For controls, numbers one through four above as well as any history of depression or the use of antidepressants
Study is available at: Duke University Medical Center
Durham, NC 27701
United States

Primary Contact:
John L Beyer, M.D
Email: beyer001@mc.duke.edu
Phone: 919-668-0206

Secondary Contact:
John L Beyer, M.D
Email: beyer001@mc.duke.edu
Phone: 919.668.0206
If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
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Data Source: ClinicalTrials.gov
Date Processed: March 22, 2011
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