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Genetics of ALS: Identification of Genes With Roles in Familial and Sporadic Amyotrophic Lateral Sclerosis (ALS) and Amyotrophic Lateral Sclerosis (ALS) With Frontotemporal Dementia - NCT00821132-60611(Clinical Trial 263382)



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City:  Chicago
State:  
IL
Zip Code: 60611
Conditions: Amyotrophic Lateral Sclerosis - Familial Amyotrophic Lateral Sclerosis - Amyotrophic Lateral Sclerosis With Frontotemporal Dementia - Lou Gehrig's Disease - Motor Neuron Disease - Primary Lateral Sclerosis
Purpose: The investigators long term goals are to improve diagnosis and develop effective treatments that arrest or ameliorate symptoms of ALS, and possibly delay or prevent disease onset in individuals at risk for developing familial ALS (FALS). In order to do this one must understand how disease develops at a molecular level. Identification of genes that increase risk for developing all types of ALS will reveal the pathways of molecular events that are involved in ALS. The investigators are collecting blood samples, family and medical histories of patients familial, sporadic ALS or primary lateral sclerosis(PLS)and particular family members. Samples are coded to maintain confidentiality. Travel is not necessary. As well as seeking to identify new genes implicated in ALS, the investigators continue our study of families with SOD1-ALS to more fully characterize that disease mechanism. Linkage analysis and affected relative pair analysis will be used to identify causative FALS genes and disequilibrium analysis and association studies are being done for sporadic ALS. Results from these studies will provide insight into the underlying disease mechanisms of ALS and provide targets for therapeutic interventions.
Study summary:
Criteria: Inclusion Criteria: - Patients with Amyotrophic Lateral Sclerosis or ALS and frontotemporal dementia - Selected family members, generally brothers and sisters of an ALS patient, the patient's parents Exclusion Criteria: - Under 18 years old
Study is available at: Northwestern University Feinberg School of Medicine
Chicago, IL 60611
United States

Primary Contact:
Sandra Donkervoort, MS
Email: s-donkervoort@northwestern.edu
Phone: 312 503 0154
If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
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Data Source: ClinicalTrials.gov
Date Processed: March 22, 2011
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