View Clinical Trial (Medical Research Study)
Effect of Cosopt Versus Combigan on Retinal Vascular Autoregulation in Primary Open Angle Glaucoma (POAG) - NCT00824824-02114(Clinical Trial 264564)
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Boston |
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State:
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MA |
| Zip Code: |
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02114 |
| Conditions: |
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Glaucoma |
| Purpose: |
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We have completed a study in which we examined the response of the retinal circulation to
changes in posture from sitting to lying down in patients with primary open angle glaucoma
(POAG). This alteration in position produces changes in the local blood pressure at the
entrance to the retinal vasculature. In a healthy retina, the vasculature adapts by
dilating and constricting in order to maintain a steady blood flow rate. In an eye with
POAG, this often does not occur. As a result, there are large fluctuations in blood flow
which may produce the retinal neuronal damage associated with glaucoma.
The purpose of this study is to demonstrate that topical anti-glaucoma treatments with
agents that have vasoactive as well as IOP-lowering effects can have a beneficial effect on
maintaining a steady retinal blood flow rate even when there are changes in local blood
pressure.
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| Study summary: |
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| Criteria: |
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Inclusion Criteria:
- POAG
- Age 40 to 80 years
- Untreated IOP greater than 21 mm Hg
Exclusion Criteria:
- More than two IOP lowering medications
- Exfoliation or pigment dispersion syndrome
- Diabetic retinopathy
- History of ocular surgery |
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| Study is available at: |
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Massachusetts Eye and Ear Infirmary Boston, MA 02114 United States
Primary Contact: Louis R Pasquale, MD Email: Louis_Pasquale@meei.harvard.edu Phone: 617-573-4270 |
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If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
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| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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March 22, 2011 |
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