A2ALL Human Liver Explants for HIF-1 Alpha Analysis/Comparison (HIF HCC) - NCT00866957-60611 (Clinical Trial 279824)
Permalink: http://www.ClinicalConnection.com/exp/ExpandedPatientViewStudy279824.aspx
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Chicago |
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State:
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IL |
| Zip Code: |
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60611 |
| Conditions: |
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Liver Cancer |
| Purpose: |
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The purpose of the study is to compare levels of HIF-1 α (Hypoxia Inducing Factor 1-alpha)
in patients who have been treated with various types of liver cancer treatments.
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| Study summary: |
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In the currently ongoing retrospective aspect of the study, we will obtain pathologic tumor
explant specimens from the tumor explant population from 8/1/1994 to 12/31/2005. We will
prepare 5-10 slides from each tumor explant block and measure HIF-1α using
immunohistochemical staining. We will also be performing a retrospective chart review for
specific data points which we believe are needed to assist us in our analysis of the
histopathologic specimens.
In addition, we will be looking at data in the United Network for Organ Sharing (UNOS)
database: www.unos.org, which will allow us to develop a more thorough and robust analysis
of the subject's experience with liver cancer. This is a public, mandatory reporting
vehicle that the government mandates all transplant centers to report to. Even if the
subject was transplanted at Northwestern, and moved, accessing UNOS data will allow us to
see what the morbidity/mortality for that patient is.
Secondly, we will start enrolling subjects in a prospective fashion. Those that either have
been treated, those currently undergoing treatment, or those newly diagnosed. From these
subjects we will obtain informed consent to; a) look at the medical records (current, future
and retrospective data), b) collect blood specimens for future analysis and correlation with
their explant slide data, c) allow us to follow these subjects indefinitely to obtain
ongoing outcomes data, morbidity and mortality information. |
| Criteria: |
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Inclusion Criteria:
- Adults, any gender ≥ to 18 years of age
- Previous, or current diagnosis of hepatocellular carcinoma (clinical or biopsy
proven)
- Resection for hepatoma and/or transplant
- Patients with diagnosis of hepatocellular carcinoma from 8/1/94 thru 12/31/05
(retrospective) with biopsy, explant and/or liver transplantation here at NMH.
- Patients previously diagnosed or, recently diagnosed with liver cancer that were
treated, currently are being treated our will potentially undergo treatment for the
disease.
Exclusion Criteria:
- Any subject outside of the above inclusion criteria |
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| Study is available at: |
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Northwestern Memorial Hospital
Chicago, IL 60611
United States
Primary Contact:
Patrice Al-Saden, RN, CCRC
Email: palsaden@northwestern.edu
Phone: 312-503-1058 |
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If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
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| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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March 16, 2010 |
Modifications to
this listing: |
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Only selected fields are shown, please use the link
above to view all information about this clinical trial. |
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Clinical trials are medical research studies designed to test the safety and/or
effectiveness of new drugs, devices, or treatments in humans. These studies are
conducted worldwide for a range of conditions and illnesses. Learn more about
clinical research and participating in a study at
About Clinical Trials.
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