View Clinical Trial (Medical Research Study)

Neurobiological Correlates of Post Traumatic Stress Disorder (PTSD) During Rapid Eye Movement (REM) Sleep - NCT00871650-15213(Clinical Trial 281177)



ClinicalConnection.com has recently undergone an update and this page may no longer be up-to-date. Please Search For Clinical Trials to view the most current clinical trials listings.


Signup
City:  Pittsburgh
State:  
PA
Zip Code: 15213
Conditions: Post-Traumatic Stress Disorder
Purpose: The overarching aim of this Exploratory/Developmental Research Grant Award (R21) is to explore the neurobiological correlates of PTSD during REM sleep by using state-of-the science positron emission tomography (PET) sleep imaging. This study will allow us to gain insight into the differences in sleep and waking brain mechanisms between veterans with PTSD and those without PTSD.
Study summary:
Criteria: General Inclusion Criteria: - Male OIF/OEF returnees between the ages of 18 and 45 years old - Combat Exposure Scale score > 17 - Not taking medications known to affect sleep or wake function for at least 2 weeks (6 weeks for fluoxetine). - No history of trauma before age 18 Specific Inclusion Criteria for Subjects with PTSD: - Meet diagnostic criteria for current PTSD according to the CAPS-1 - CAPS-1 score is less than 80 Specific Inclusion Criteria for Subjects without PTSD: - Total CAPS-1 scores < 17 - Does not meet criteria for PTSD Exclusion Criteria: - Trauma occurred less than 3 months prior to study entry - CES score < 17 - Taking medications known to affect sleep and / or brain glucose metabolism - Current diagnosis of depression as determined by the SCID or BDI score > 13 - History of psychotic or bipolar disorder - Current history (within 3 months) of substance or alcohol abuse as determined by the SCID - Positive alcohol blood test at screening or during the PET protocol - Significant or unstable acute or chronic medical conditions - Other current sleep disorders, such as insufficient sleep syndrome, delayed sleep phase syndrome, narcolepsy, restless legs syndrome, periodic leg movement disorder, obstructive sleep apnea, and current night shift work, suspected during the structured interview. Individuals who are found to have a apnea-hypopnea index (AHI) > 10 or an index of periodic leg movements with arousal > 15 will be excluded. - Presence of implanted devices such as cardiac pacemaker, aneurysm clip, ear implant, shrapnel, neurostimulators or other metal devices - Fear of closed spaces - Previous radiation. Due to the risk of radiation exposure, we will exclude subjects who have had PET scans or other radiotracer exposure in the previous year. - History of open head injury.
Study is available at: University of Pittsburgh
Pittsburgh, PA 15213
United States

Primary Contact:
Anne Germain, Ph.D.
Email: germaina@upmc.edu
Phone: 412-246-6436

Secondary Contact:
Anne Germain, Ph.D.
Email: germaina@upmc.edu
Phone: 412-246-6436
If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
Trials Alerts: If you would like to be notified of new clinical trials as they become available please register for a free account.
Data Source: ClinicalTrials.gov
Date Processed: March 23, 2011
Modifications to
this listing:		 Only selected fields are shown, please use the link above to view all information about this clinical trial.