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Metabolics of Roux-en-Y Gastric Bypass (RYGB) With Gastrostomy - NCT00887302-(Clinical Trial 288615)



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City:  Greenville
State:  
NC
Zip Code:
Conditions: Type II Diabetes Mellitus - Obesity
Purpose: This study is an investigation of the "metabolics of RYGB with gastrostomy."
Study summary: The rapid and durable remission of type II diabetes mellitis following the gastric bypass operation challenges the current concepts about the etiology of the disease. The surgery, which excludes food from the stomach, duodenum, and proximal jejunum, is quickly followed by a durable drop in glucose and insulin levels. As a result, 4 out of 5 diabetic, morbidly obese individuals who undergo the operation return to a long-term euglycemia with a prolongation of life and a reduction of health care costs. The investigators at East Carolina University and those at Johnson and Johnson propose to further complete the profile of the upper gut by extending their observation to three additional human models. The investigators will study patients having the gastric band procedure, the gastric sleeve procedure, and those who have a gastric bypass but have a PEG tube inserted later.
Criteria: Inclusion Criteria: - Female - 18-60 years of age - BMI of 35-65 - Willing to comply with study requirements and long term follow-up - Capable of understanding the requirements and consequences of surgery and the study - Is scheduled to have bariatric surgery performed - Has a negative pregnancy test Exclusion Criteria: - Repeat gastric bypass procedure - Patients who are unable to hold their insulin coverage for 48 hours prior to research visits - Patients taking TZDs
Study is available at: East Carolina University Brody School of Medicine
Greenville, NC
United States
If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
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Data Source: ClinicalTrials.gov
Date Processed: March 23, 2011
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