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View Clinical Trial (Medical Research Study)
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A Pilot Study of Lenalidomide, Melphalan and Dexamethasone in AL Amyloidosis - NCT00890552-94305 (Clinical Trial 289405)
Permalink: http://www.ClinicalConnection.com/exp/ExpandedPatientViewStudy289405.aspx
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| City: |
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Stanford |
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State:
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CA |
| Zip Code: |
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94305 |
| Conditions: |
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Leukemia - Amyloidosis |
| Purpose: |
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This open-label trial will evaluate a dose of oral lenalidomide 10 mg taken daily on days
1-21 of 28 day cycle. Oral melphalan 0.18mg/kg will be taken on days 1-4 of a 28 day cycle.
Oral dexamethasone 40 mg will be taken on days 1, 8, 15 and 22 of a 28 day cycle. Up to 15
patients over the age of 18 with newly diagnosed or relapsed AL amyloidosis will be included
in this study. In the absence of disease progression or toxicity, patients will complete
nine cycles of therapy. After nine cycles, subjects have the option of continuing
lenalidomide therapy alone. The primary objective of this study is safety and tolerability
of the above regimen. The secondary objectives are hematologic and organ responses, as well
as time to progression.
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| Study summary: |
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| Criteria: |
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Inclusion Criteria:
1. Understand and voluntarily sign an informed consent form.
2. Age >=18 years at the time of signing the informed consent form.
3. Able to adhere to the study visit schedule and other protocol requirements.
4. Newly diagnosed or relapsed AL amyloidosis.
5. Biopsy-proven amyloidosis with evidence of an underlying plasma cell dyscrasia
(abnormal clonal dominance of plasma cells in the bone marrow, and/or detection of a
monoclonal gammopathy by immunofixation electrophoresis of serum and/or urine, and/or
an abnormal serum free light chain or ratio, or AL fibrils seen on biopsy).
6. Measurable disease, defined by an abnormal serum free light chain or monoclonal
protein by immunofixation, proteinuria >= 0.5g/day, cardiac involvement with
interventricular septal thickness >= 15mm, or hepatomegaly in the absence of
congestive heart failure with elevated alkaline phosphatase.
7. All previous cancer therapy, including radiation, hormonal therapy and surgery, must
have been discontinued at least 4 weeks prior to treatment in this study.
8. ECOG performance status of <= 3 at study entry (see Appendix II).
9. Laboratory test results within these ranges:
- Absolute neutrophil count >= 1.0 x 10^9/L.
- Platelet count >= 75 x 10^9/L
- Creatinine clearance >= 15mL/minute (calculated by MDRD Equation or
Cockcroft-Gault, or measured by 24-hour urine collection).
- Total bilirubin <= 2-fold upper limits of normal.
10. Disease free of prior malignancies (excluding multiple myeloma) for >= 3 years with
exception of currently treated basal cell, squamous cell carcinoma of the skin, or
carcinoma "in situ" of the cervix or breast.
11. All study participants must be registered into the mandatory RevAssist program, and
be willing and able to comply with the requirements of RevAssist.
12. Females of childbearing potential (FCBP)† must have a negative serum or urine
pregnancy test with a sensitivity of at least 50 mIU/mL within 10 - 14 days prior to
and again within 24 hours of prescribing lenalidomide (prescriptions must be filled
within 7 days) and must either commit to continued abstinence from heterosexual
intercourse or begin TWO acceptable methods of birth control, one highly effective
method and one additional effective method AT THE SAME TIME, at least 28 days before
she starts taking lenalidomide. FCBP must also agree to ongoing pregnancy testing.
Men must agree to use a latex condom during sexual contact with a FCBP even if they
have had a successful vasectomy. See Appendix: Risks of Fetal Exposure, Pregnancy
Testing Guidelines and Acceptable Birth Control Methods.
13. Able to take aspirin (81 mg) daily or alternative (see below) as prophylactic
anticoagulation. Patients intolerant to aspirin may use coumadin or low molecular
weight heparin. Patients requiring full dose anticoagulation for a prior thrombosis
can take low molecular weight heparin (preferred) or coumadin instead of aspirin.
Exclusion Criteria:
1. Any serious medical condition, laboratory abnormality, or psychiatric illness that
would prevent the subject from signing the informed consent form.
2. Pregnant or breast feeding females. (Lactating females must agree not to breast feed
while taking lenalidomide).
3. Use of any other experimental drug or therapy within 28 days of baseline.
4. Known hypersensitivity to thalidomide.
5. The development of erythema nodosum if characterized by a desquamating rash while
taking thalidomide or similar drugs.
6. Any prior use of lenalidomide.
7. Concurrent use of other anti-cancer agents or treatments.
8. Known positive for HIV. |
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| Study is available at: |
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Stanford University School of Medicine
Stanford, CA 94305
United States
Primary Contact:
Terra R Coakley
Email: tcoakley@cvmed.stanford.edu
Phone: 650-725-6186
Secondary Contact:
Terra R Coakley
Email: tcoakley@cvmed.stanford.edu
Phone: (650) 725-6186 |
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If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
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| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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November 16, 2009 |
Modifications to
this listing: |
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Only selected fields are shown, please use the link
above to view all information about this clinical trial. |
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Clinical trials are medical research studies designed to test the safety and/or
effectiveness of new drugs, devices, or treatments in humans. These studies are
conducted worldwide for a range of conditions and illnesses. Learn more about
clinical research and participating in a study at
About Clinical Trials.
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