Study of the Effect of Fluticasone Furoate Nasal Spray on Spring Allergy Eye Symptoms - NCT00891436-60612 (Clinical Trial 289940)


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Study of the Effect of Fluticasone Furoate Nasal Spray on Spring Allergy Eye Symptoms - NCT00891436-60612 (Clinical Trial 289940)
Permalink: http://www.ClinicalConnection.com/exp/ExpandedPatientViewStudy289940.aspx

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City:

Chicago

State:

Zip Code:

60612

Conditions:

Allergic Conjunctivitis to Tree Pollen or Grass Pollen

Purpose:

Rationale and objectives: Fluticasone furoate nasal spray (Veramyst) has been shown to improve ocular symptoms when used for the treatment of seasonal allergic rhinitis during the ragweed pollen season. Although this is the only published report of an intranasal corticosteroid shown to effectively treat ocular symptoms, the mechanism has not been delineated. Furthermore, the tears of patients with allergic conjunctivitis are known to have increased concentrations of cytokines and allergic mediators. The objective of this study is to determine if the positive effects of Veramyst nasal spray on ocular symptoms is via the inhibition of allergic mediators in the eyes. The investigators will conduct a double blind placebo controlled trial to determine if Veramyst nasal spray decreases the amount of allergic mediators in the tears of subjects randomized to Veramyst nasal spray versus placebo. The investigators will also compare the subjects' symptoms to the amount of allergic mediators detected in their tears.

Study summary:

Criteria:

Inclusion Criteria: - a documented history of allergic rhinitis and conjunctivitis due to tree pollen and / or grass pollen for two allergy seasons - positive skin prick test to tree and / or grass Exclusion Criteria: - glaucoma - cataracts - acute or chronic sinusitis - asthma - chronic obstructive pulmonary disease - physical nasal obstruction - pregnant or breastfeeding - have had a viral or bacterial infections within 2 weeks of the study commencement - receiving allergen immunotherapy - have used inhaled corticosteroids within 14 days prior to the study - have used systemic corticosteroids within 30 days of the study - travel outside of the geographic area during the 2 week study period - use of contact lenses during the study period - use of artificial tears during the study period - use of eyewash irrigation during the study period - use of lubricants during the study period

Study is available at:

Rush University Medical Center
Chicago, IL 60612
United States

If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.

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Data Source:		ClinicalTrials.gov
Date Processed:		March 16, 2010
Modifications to this listing:		Only selected fields are shown, please use the link above to view all information about this clinical trial.

Clinical trials are medical research studies designed to test the safety and/or effectiveness of new drugs, devices, or treatments in humans. These studies are conducted worldwide for a range of conditions and illnesses. Learn more about clinical research and participating in a study at About Clinical Trials.


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