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Blood Samples From Patients With Non-Small Cell Lung Cancer and From Healthy Volunteers - NCT00897234-55455(Clinical Trial 290928)



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City:  Minneapolis
State:  
MN
Zip Code: 55455
Conditions: Lung Cancer
Purpose: RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research study is looking at blood samples from patients with non-small cell lung cancer and from healthy volunteers.
Study summary: OBJECTIVES: - Measure plasma cathepsin D levels in patients with non-small cell lung cancer and in healthy volunteers using mass spectometry. - Measure fatty acid synthase levels in these patients and healthy volunteers using mass spectometry. OUTLINE: Blood samples are collected from patients and healthy volunteers to measure the levels of cathepsin D and fatty acid synthase by proteomic profiling and mass spectrometry.
Criteria: Inclusion Criteria: Non-Small Cell Lung Cancer Patients - Documented diagnosis of non-small cell lung cancer, any stage and any time point in the course of treatment (i.e., at diagnosis, during any treatment, and during post treatment surveillance) - Measurable disease by CT scan within the past 4 weeks Healthy volunteer - Non-smoking, defined as < 5 packs/year history of smoking and cessation of smoking ≥ 6 months ago OR a never smoker - Not regularly exposed (i.e., daily) to second-hand smoke Exclusion Criteria: - Severe underlying lung disease (i.e., chronic obstructive pulmonary disease with FEV_1 < 1.0 L, pulmonary fibrosis, bronchiectasis, cystic fibrosis, etc.) as determined by enrolling researcher. Written consent must be given for both subjects and controls.
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Data Source: ClinicalTrials.gov
Date Processed: November 11, 2010
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