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Collecting Stem Cells in Patients With Waldenstrom's Macroglobulinemia - NCT00899119-10032(Clinical Trial 291396)



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City:  New York
State:  
NY
Zip Code: 10032
Conditions: Lymphoma
Purpose: RATIONALE: Collecting and storing stem cells to study in the laboratory may help doctors learn more about collecting stem cells from patients who have undergone treatment for Waldenstrom's macroglobulinemia. PURPOSE: This laboratory study is collecting stem cells from patients with Waldenstrom's macroglobulinemia.
Study summary: OBJECTIVES: - Harvest and store adequate CD34+ stem cells from patients with Waldenstrom's macroglobulinemia (WM) for potential future use in transplantation strategies. - Evaluate the ability to harvest stem cells after therapy for WM (e.g., fludarabine-based chemotherapy) by evaluating the number of days to adequate harvest. - Collect aliquots of stem cells for future research analysis as part of a WM database project. OUTLINE: Patients undergo collection of autologous stem cells beginning on day 4 or 5 and continuing until an adequate number of stem cells are collected. Cells are then cryopreserved. PROJECTED ACCRUAL: A total of 40 patients will be accrued for this study.
Criteria: DISEASE CHARACTERISTICS: - Diagnosis of Waldenstrom's macroglobulinemia (WM) - Less than 30% lymphoplasmacytoid cells in bone marrow by histopathology - Received prior chemotherapy for WM PATIENT CHARACTERISTICS: - ECOG performance status 0-1 - WBC > 2,000/mm³ - Platelet count > 50,000/mm³ - LVEF ≥ 50% - No organ dysfunction that would preclude future transplantation PRIOR CONCURRENT THERAPY: - See Disease Characteristics
Study is available at: Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center
New York, NY 10032
United States

Primary Contact:
Clinical Trials Office - Herbert Irving Comprehensive Cancer C
Phone: 212-305-8615
If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
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Data Source: ClinicalTrials.gov
Date Processed: March 23, 2011
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