View Clinical Trial (Medical Research Study)
Changes in DNA After Radiation Therapy in Patients With Prostate Cancer - NCT00899912-54601(Clinical Trial 291458)
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La Crosse |
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State:
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WI |
| Zip Code: |
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54601 |
| Conditions: |
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Prostate Cancer |
| Purpose: |
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RATIONALE: Collecting and storing samples of tissue from patients with cancer to study in
the laboratory may help doctors learn more about changes that may occur in DNA after
radiation therapy and identify biomarkers related to cancer.
PURPOSE: This laboratory study is looking at changes in DNA after radiation therapy in
patients with prostate cancer.
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| Study summary: |
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OBJECTIVES:
Primary
- Demonstrate the feasibility of acquiring specimens, both frozen and paraffin-embedded,
to yield RNA of adequate quality to perform DNA microarray studies on markers of
radiotherapy outcome in patients with intermediate-risk prostate cancer.
Secondary
- Compare the gene expression results from frozen tissue and paraffin-embedded tissue to
see the correlation between the 2 methods in patients treated on the brachytherapy
alone arm of protocol RTOG-0232.
- Find genes that are expressed differentially before and after radiation therapy in
patients treated on the brachytherapy plus external-beam radiation therapy arm of
protocol RTOG-0232.
- Find gene expression patterns in patients treated on either arm of protocol RTOG-0232
who have significant associations with biochemically as well as clinically apparent
local and distant failure.
OUTLINE: This is a multicenter, pilot study.
Frozen and paraffin-embedded tissue samples are studied for biomarker/laboratory analysis.
DNA microarray analysis is performed on the samples to assess markers of radiotherapy
outcome.
PROJECTED ACCRUAL: A total of 156 patients will be accrued for this study. |
| Criteria: |
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DISEASE CHARACTERISTICS:
- Diagnosis of prostate cancer
- Stage II disease
- Adenocarcinoma
- Eligible for and enrolled on protocol RTOG 0232
- Able to submit frozen tissue cores from biopsy specimens obtained at the time of
brachytherapy
PATIENT CHARACTERISTICS:
- Not specified
PRIOR CONCURRENT THERAPY:
- No prior neoadjuvant hormonal therapy |
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If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
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| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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August 16, 2010 |
Modifications to
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