|
|
View Clinical Trial (Medical Research Study)
|
Effectiveness of Cognitive Enhancement Therapy for Young Adults With Autism Spectrum Disorders - NCT00902798-15213 (Clinical Trial 292550)
Permalink: http://www.ClinicalConnection.com/exp/ExpandedPatientViewStudy292550.aspx
|
** Please review additional "Nearby Studies" on right ----->
|
|
 |
 |
|
| City: |
|
Pittsburgh |
|
State:
|
|
PA |
| Zip Code: |
|
15213 |
| Conditions: |
|
Autistic Disorder |
| Purpose: |
|
This study will test a therapy for improving thinking and brain function in people with
autism, Asperger's syndrome, or pervasive developmental disorder.
|
| Study summary: |
|
Autism, Asperger's syndrome, and pervasive developmental disorder are all autism spectrum
disorders (ASD), which are characterized by specific impairments in social interactions,
communication, and imaginative play and by restricted and repetitive interests and behavior.
These impairments stem from problems in underlying cognition and information processing.
ASDs are often treated in childhood, but no attempt has been made to improve cognition and
brain deficits in adults with ASDs, who often experience difficulty in understanding social
situations, thinking abstractly, and taking the perspective of others. Cognitive enhancement
therapy (CET) is a treatment that has proved effective in improving cognition in individuals
with schizophrenia. This study will test whether CET can improve cognition and brain
functioning in adults with ASDs.
Participation in this study will last 18 months. Potential participants must be able to
attend weekly treatment sessions in Pittsburgh, PA. The first 12 participants will be
assigned to receive CET. All other participants will be randomly assigned to receive either
CET or usual care as part of the control group. Some participants will also be randomly
selected to complete a magnetic resonance imaging (MRI) assessment, which will involve
performing tasks while undergoing a brain scan. Participants assigned to receive CET will
complete three different weekly study visits: a group, an individual, and a computer visit.
Participants will receive training in attention, memory, and problem solving abilities
through computer training and will develop problem solving and communication skills through
the group sessions. The CET treatment will require approximately 3 to 3.5 hours a week for
up to 18 months.
All participants will complete assessments at baseline and after 9 and 18 months.
Assessments will include a cognitive testing session, in which participants complete a
reading and intelligence test; an interview with a researcher, in which participants will be
asked about the symptoms of their disorder; and an interview with a family member or close
friend of the participant, which will involve questions about the participant's disorder.
Participants assigned to MRI will undergo the procedure at baseline and 18 months. |
| Criteria: |
|
Inclusion Criteria:
- Diagnosis of autism, Asperger's syndrome, or pervasive developmental disorder not
otherwise specified (NOS) verified by the autism diagnostic observation schedule
(ADOS) and autism diagnostic interview-revised (ADI-R)
- Presence of significant social and cognitive disability, based on the cognitive style
and social cognition eligibility interview
- Intelligence quotient (IQ) greater than 80
- Ability to read and speak fluent English
- Ability to attend weekly treatment sessions in Pittsburgh, PA
Exclusion Criteria:
- Organic brain syndrome
- English language skills below a sixth grade level
- Persistent suicidal or homicidal behavior
- History of substance abuse or dependence within the past 3 months
- Comorbid attention deficit hyperactivity disorder (ADHD) |
|
|
|
| Study is available at: |
|
University of Pittsburgh
Pittsburgh, PA 15213
United States
Primary Contact:
Dave Maloney
Email: autismrecruiter@upmc.edu
Phone: 1-866-647-3436 |
|
|
If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
|
| Trials Alerts: |
|
If you would like to be
notified of new clinical trials as they become available please
register for a free account.
|
|
| Data Source: |
|
ClinicalTrials.gov |
| Date Processed: |
|
March 16, 2010 |
Modifications to
this listing: |
|
Only selected fields are shown, please use the link
above to view all information about this clinical trial. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| |
|
|
| |
|
|
| |
|
|
| |
|
|
| |
|
|
| |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Clinical trials are medical research studies designed to test the safety and/or
effectiveness of new drugs, devices, or treatments in humans. These studies are
conducted worldwide for a range of conditions and illnesses. Learn more about
clinical research and participating in a study at
About Clinical Trials.
|
|
|
|
|
|
|
|