View Clinical Trial (Medical Research Study)
Brain Activity, Genes, and Smoking - NCT00915798-92612(Clinical Trial 297051)
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| City: |
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Irvine |
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State:
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CA |
| Zip Code: |
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92612 |
| Conditions: |
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Smoking - Abstinence |
| Purpose: |
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The study investigates the underlying mechanisms of smoking in 150 young adults by examining
the associations between smoking, prefrontal-limbic brain circuitry, dopamine genes, and
attention deficit hyperactivity disorder (ADHD). Four groups of young adults will be
recruited: (1) smokers with ADHD; (2) nonsmokers with ADHD; (3) normative control smokers;
and (4) normative control nonsmokers. Smoking will be assessed via questionnaires and
salivary cotinine levels. Prefrontal-limbic brain circuitry will be examined via functional
Magnetic Resonance Imaging (fMRI), Diffusion Tensor Imaging (DTI), and Near-Infrared
Spectroscopy (NIRS). Candidate genes will be the dopamine receptor (DRD4) and transporter
(DAT1). Each nonsmoker will undergo a DTI scan and an fMRI scan during an experimental task
consisting of mathematical problems and unpleasant and neutral pictures. Smokers will
undergo a DTI scan, one NIRS session, and two fMRI scans during similar experimental tasks
under the following two conditions: (1) after smoking a cigarette and (2) after overnight
abstinence. The findings will provide information on the effects of smoking and abstinence
on prefrontal-limbic brain circuitry in smokers with and without ADHD. In addition, the
study will explore smoking in individuals with DRD4 and DAT1 and their potential interaction
with prefrontal-limbic brain circuitry.
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| Study summary: |
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| Criteria: |
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Inclusion Criteria:
1. Smokers with ADHD
- Cigarette smoking for the last year
- ADHD diagnosis
2. Nonsmokers with ADHD
- No history of regularly smoking cigarettes
- ADHD diagnosis
3. Normative control smokers
- Cigarette smoking for the last year
- No history and diagnosis of ADHD
4. Normative control nonsmokers
- No history of regularly smoking cigarettes
- No history and diagnosis of ADHD
Exclusion Criteria:
- Children under the age of 18
- Adults above the age of 45
- Pregnancy or planning to become pregnant
- Any major medical illness
- Any mental disorders that require medication (except stimulant medication)
- Any contraindications to fMRI scanning
- Not speaking English |
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| Study is available at: |
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19722 MacArthur Blvd.
Irvine, CA 92612
United States
Primary Contact:
Jean Gehricke, Ph.D.
Email: jgehrick@uci.edu
Phone: 949-824-1834
Secondary Contact:
Jean Gehricke, Ph.D.
Email: jgehrick@uci.edu
Phone: 949-824-1834 |
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If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
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| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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March 23, 2011 |
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